Li Ruiyuan, Guo Lipeng, Liang Bin, Sun Wei, Hai Feng
Graduate School of Jinzhou Medical University, Jinzhou, Liaoning, China.
Department of Cardiology, Dalian Third People's Hospital of Jinzhou Medical University, Dalian, 116033, Liaoning, China.
Open Med (Wars). 2025 Feb 27;20(1):20251159. doi: 10.1515/med-2025-1159. eCollection 2025.
The immune system is closely related to hypertension. Hypertension is an immune disorder to a certain extent, and inflammation is the basis of abnormally elevated blood pressure (BP). The accumulation of T cells and their cytokines can increase BP and end organ damage. T cells are activated by antigen-presenting cells of the innate immune system or by the influence of a high-sodium diet, the self-environment, or the gut microbiota. These cells produce inflammatory factors and cytokines, such as interleukin-17A (IL-17A) in T helper 17 cells, causing vascular inflammation, hypertension, and target organ damage.
In this article, we provide an insightful review of the research progress regarding the role of IL-17A in the pathogenesis of hypertension and its effects on different organs while emphasizing the role of IL-17A and its mediated functions in the kidneys, brain, intestines, and vascular system in the development and progression of hypertension.
At the organ level, IL-17A is involved in the development and progression of hypertension in the kidneys, brain, intestines, and blood vessels, interacting with multiple signal pathway.
These findings have significant implications for developing future immunomodulatory therapies, which may lead to the development of potential treatments for hypertension.
免疫系统与高血压密切相关。高血压在一定程度上是一种免疫紊乱，炎症是血压异常升高的基础。T细胞及其细胞因子的积累会增加血压并导致靶器官损伤。T细胞可被先天性免疫系统的抗原呈递细胞激活，或受高钠饮食、自身环境或肠道微生物群的影响。这些细胞产生炎症因子和细胞因子，如辅助性T细胞17中的白细胞介素-17A（IL-17A），导致血管炎症、高血压和靶器官损伤。
在本文中，我们对IL-17A在高血压发病机制中的作用及其对不同器官的影响的研究进展进行了深入综述，同时强调了IL-17A及其介导的功能在高血压发生和发展过程中在肾脏、大脑、肠道和血管系统中的作用。
在器官水平上，IL-17A参与肾脏、大脑、肠道和血管中高血压的发生和发展，并与多种信号通路相互作用。
这些发现对未来免疫调节疗法的开发具有重要意义，这可能会带来高血压潜在治疗方法的发展。
