Regenstein F G, Perrillo R P, Bodicky C, Stern K, Zelman S
Vaccine. 1985 Mar;3(1):27-30. doi: 10.1016/0264-410x(85)90006-4.
Eighteen patients on chronic dialysis (15 haemodialysis, three peritoneal) were evaluated to determine whether certain clinical features and/or in vitro indicators of immune function correlated with the response to hepatitis B vaccine. Only 44% of patients developed antibody to hepatitis B surface antigen (anti-HBS) following vaccination and neither duration of dialysis, history of renal transplant, peripheral T cell numbers, T4/T8 ratios, nor mitogen induced lymphocyte proliferation correlated with response to vaccination. Advanced age, history of multiple blood transfusions and depressed levels of IgM may be associated with a poor antibody response to the vaccine. Future studies need to consider these variables when evaluating immunogenicity of new hepatitis B vaccine preparations.
对18例慢性透析患者（15例血液透析，3例腹膜透析）进行了评估，以确定免疫功能的某些临床特征和/或体外指标是否与乙肝疫苗的反应相关。接种疫苗后，只有44%的患者产生了乙肝表面抗原抗体（抗-HBs），透析时间、肾移植史、外周血T细胞数量、T4/T8比值以及丝裂原诱导的淋巴细胞增殖均与疫苗反应无关。高龄、多次输血史和IgM水平降低可能与疫苗抗体反应不佳有关。未来研究在评估新型乙肝疫苗制剂的免疫原性时需要考虑这些变量。
