Callis L M, Clanxet J, Fortuny G, Caballeria J, Carrasco J L, Lardinois R
Acta Paediatr Scand. 1985 Mar;74(2):213-8. doi: 10.1111/j.1651-2227.1985.tb10952.x.
Among 54 patients, between 2 and 18 years of age, submitted to hemodialysis due to severe chronic renal failure, the prevalence of hepatitis B virus markers was 66.7% and that of HBsAg was 13.0%. Eighteen children, with no evidence of hepatitis B virus infection, were vaccinated. Following three vaccine injections, only 2 patients did not respond and a third one developed low anti-HBs titers. The vaccine was well tolerated. No relationship was observed between the intensity of the humoral immune response and age, sex, type of renal disease and time on dialysis. Seroconversion rates (87.5%) and geometric means of anti-HBs titers (greater than 4 000 Ausab Units) of these patients are similar to those observed following vaccination of healthy adults.
在54例因严重慢性肾衰竭接受血液透析的2至18岁患者中，乙肝病毒标志物的流行率为66.7%，HBsAg的流行率为13.0%。18名无乙肝病毒感染证据的儿童接种了疫苗。三次注射疫苗后，只有2例患者无反应，另有1例抗-HBs滴度较低。疫苗耐受性良好。未观察到体液免疫反应强度与年龄、性别、肾病类型及透析时间之间存在关联。这些患者的血清转化率（87.5%）和抗-HBs滴度几何均值（大于4000 Ausab单位）与健康成人接种疫苗后观察到的情况相似。
