Lim Enoch Chi Ngai, Cheng Nga Chong Lisa, Lim Chi Eung Danforn
Research and Development, Specialist Medical Services Group, Earlwood, AUS.
School of Life Sciences, University of Technology Sydney, Sydney, AUS.
Cureus. 2025 Feb 26;17(2):e79671. doi: 10.7759/cureus.79671. eCollection 2025 Feb.
Doxycycline is commonly used in respiratory medicine to treat bacterial lower respiratory tract infections and is also a frequent choice in dermatology for various skin conditions. However, neuropsychiatric adverse reactions to doxycycline are rarely documented in the literature. Even less frequently reported is the persistence of such reactions for up to six weeks after discontinuing a 100 mg doxycycline tablet. We present a rare case of doxycycline-induced mania and psychosis in a patient who had taken the antibiotic for only three days, yet experienced severe neuropsychiatric symptoms that lasted for six weeks after treatment cessation. This case highlights the need for further research to identify the underlying mechanisms, high-risk populations, and implications for informed consent and clinical recommendations.
多西环素常用于呼吸医学中治疗细菌性下呼吸道感染，在皮肤科治疗各种皮肤疾病时也是常用选择。然而，文献中很少记录多西环素的神经精神不良反应。更罕见的报道是，在停用100毫克多西环素片后，此类反应持续长达六周。我们报告了一例罕见的多西环素诱发的躁狂和精神病病例，该患者仅服用了三天抗生素，但在停药后出现了严重的神经精神症状，并持续了六周。该病例凸显了进一步研究以确定潜在机制、高危人群以及对知情同意和临床建议的影响的必要性。
