Chen Chuchu, Qiu Kaiyan
School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, USA.
Methods Mol Biol. 2025;2902:183-195. doi: 10.1007/978-1-0716-4402-7_12.
Medical errors are one of the leading death causes in the United States, becoming a serious concern in clinical surgeries. Although full elimination of medical errors is unattainable, proper surgical planning and rehearsals on presurgical artificial organ models can reduce the error occurrences. However, current organ models miss multiple important features, such as a lack of tissue-mimicking properties and quantitative sensing feedback, significantly limiting their capabilities in advanced surgical planning and rehearsal. Therefore, the design and development of new methods and customized inks to fabricate patient-specific 3D-printed artificial organ models with accurate tissue-mimicking sensation and real-time operation feedback can be greatly beneficial to surgical applications and outcomes.This chapter introduces relevant fabrication, properties, characterization, and applications of 3D-printed patient-specific prostate models with physical properties of tissue and integrated soft electronic sensors.
医疗差错是美国主要的死亡原因之一,已成为临床手术中一个严重令人担忧的问题。尽管完全消除医疗差错是无法实现的,但在术前人造器官模型上进行适当的手术规划和预演可以减少差错的发生。然而,目前的器官模型缺少多个重要特征,如缺乏组织模拟特性和定量传感反馈,这严重限制了它们在先进手术规划和预演中的能力。因此,设计和开发新的方法以及定制墨水,以制造具有精确组织模拟感觉和实时操作反馈的患者特异性3D打印人造器官模型,可能会极大地有利于手术应用和结果。本章介绍了具有组织物理特性和集成软电子传感器的3D打印患者特异性前列腺模型的相关制造、特性、表征和应用。