Alaparthi Gopala Krishna, Moustafa Ibrahim Moustafa, Lopes Agnaldo José, Ferreira Arthur de Sá
Augusto Motta University Center, UNISUAM, Rio de Janeiro, Brazil.
Department of Health Professions, Manchester Metropolitan University, Manchester, United Kingdom.
PLoS One. 2025 Mar 3;20(3):e0316663. doi: 10.1371/journal.pone.0316663. eCollection 2025.
Asthma may lead to musculoskeletal dysfunction, including postural abnormalities. This study aimed to compare pulmonary function, body posture, and dynamic balance in young adults with childhood-onset asthma and healthy peers. This cross-sectional study included 124 participants evenly split between asthma and healthy groups. Assessments covered pulmonary function, respiratory muscle strength, postural balance, and body posture. We observed differences between groups in pulmonary function variables and respiratory muscle strength (Forced Expiratory Volume in the First Second (FEV 1); p = 0.005, forced vital capacity (FVC);.p = 0.002, peak expiratory flow rate (PEFR); p = 0.03) and respiratory muscle strength (maximal. expiratory pressure (MEP); p = 0.05). There was no difference in postural balance and body posture between groups. Moderate correlations were noted between postural balance (double leg eye closed) and pulmonary function (r = 0.38-0.43; p < 0.001), but not between body posture and pulmonary function. These findings suggest childhood-onset asthma in young adults, particularly mild to moderate cases, is associated with impaired pulmonary function and respiratory muscle strength but does not significantly impact postural balance or body posture compared to healthy peers. Trial registration: ClinicalTrials.gov NCT05373511.
哮喘可能导致肌肉骨骼功能障碍，包括姿势异常。本研究旨在比较患有儿童期起病哮喘的年轻成年人与健康同龄人之间的肺功能、身体姿势和动态平衡。这项横断面研究纳入了124名参与者，哮喘组和健康组各62人。评估内容包括肺功能、呼吸肌力量、姿势平衡和身体姿势。我们观察到两组在肺功能变量和呼吸肌力量方面存在差异（第1秒用力呼气量（FEV1）；p = 0.005，用力肺活量（FVC）；p = 0.002，呼气峰值流速（PEFR）；p = 0.03）以及呼吸肌力量（最大呼气压力（MEP）；p = 0.05）。两组之间的姿势平衡和身体姿势没有差异。姿势平衡（双腿闭眼）与肺功能之间存在中度相关性（r = 0.38 - 0.43；p < 0.001），但身体姿势与肺功能之间没有相关性。这些发现表明，年轻成年人中的儿童期起病哮喘，尤其是轻度至中度病例，与肺功能和呼吸肌力量受损有关，但与健康同龄人相比，对姿势平衡或身体姿势没有显著影响。试验注册：ClinicalTrials.gov NCT05373511。
