Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Respiratory Medicine, Zhongshan Hospital Affiliated with Fudan University, Shanghai, China.
Respir Care. 2020 May;65(5):665-672. doi: 10.4187/respcare.07116. Epub 2020 Feb 4.
In this study, we aimed to validate the agreement between pulmonary function measurements obtained with a portable spirometer and measurements obtained with conventional spirometry in Chinese pediatric and adult populations.
Pulmonary function testing was performed to evaluate subjects enrolled at Shanghai Zhongshan Hospital ( = 104) and Shanghai Children's Medical Center ( = 103). The portable spirometers and conventional devices were applied to each subject with a 20-min quiescent period between each measurement. Pulmonary function parameters of FVC, FEV, peak expiratory flow, maximum expiratory flow at 25%, 50%, and 75% of FVC (MEF, MEF, and MEF, respectively), and FEV/FVC% were compared with intraclass correlation and Bland-Altman methods.
A satisfactory concordance of pulmonary function was observed between spirometry measurements obtained with portable versus conventional spirometers. Intraclass correlation indicated excellent reliability (>0.75) for all pulmonary function indicators in pediatric and adult subjects. Significant positive correlations of all variables measured with different spirometers were observed (all < .001). No significant bias was observed in either group, although limits of agreement varied. Funnel effects were observed for peak expiratory flow in pediatric subjects and for FVC, FEV, MEF, and MEF in adult subjects.
The portable spirometer is an alternative to the conventional device for the measurement of pulmonary function. Compared with the conventional device, the portable spirometer is expected to provide convenient, operational, and financial advantages.
本研究旨在验证在中文儿科和成人人群中，使用便携式肺活量计测量的肺功能与传统肺活量计测量的肺功能之间的一致性。
在上海中山医院（n = 104）和上海儿童医学中心（n = 103）入组的受试者中进行肺功能测试。每个受试者在两次测量之间有 20 分钟的安静期，应用便携式肺活量计和传统设备进行测量。使用组内相关和 Bland-Altman 方法比较 FVC、FEV、呼气峰流速、FVC 时的 25%、50%和 75%最大呼气流量（MEF、MEF 和 MEF，分别）以及 FEV/FVC%等肺功能参数。
便携式肺活量计与传统肺活量计测量的肺功能具有良好的一致性。组内相关分析表明，在儿科和成年受试者中，所有肺功能指标的可靠性均较高（>0.75）。不同肺活量计测量的所有变量均呈显著正相关（均 P < 0.001）。两组均未观察到明显的偏倚，但一致性界限存在差异。在儿科受试者中，呼气峰流速存在漏斗效应，在成年受试者中，FVC、FEV、MEF 和 MEF 也存在漏斗效应。
便携式肺活量计是测量肺功能的传统设备的替代选择。与传统设备相比，便携式肺活量计有望提供方便、操作性和经济性优势。
