Darwin Alicia, Xie Jiayi, Smith Melody
Department of Medicine, Stanford University School of Medicine, Stanford, CA.
Division of Blood and Marrow Transplantation and Cellular Therapy, Department of Medicine, Stanford University School of Medicine, Stanford, CA.
Blood Adv. 2025 Jul 8;9(13):3356-3367. doi: 10.1182/bloodadvances.2024013809.
Antibiotics disrupt the delicate balance of bacteria, fungi, and viruses in the human microbiome. Growing evidence indicates a significant relationship between the intestinal microbiome and cellular therapy, which aligns with the established influence of the microbiome on immune responses. When examining the link between cellular therapy and the microbiome, it is essential to understand how disruptions in the microbiome, especially those caused by antibiotics, affect these therapies. Here, we discuss the impact of antibiotics on the intestinal microbiome, cellular therapy outcomes, and associated toxicities, particularly in the context of hematopoietic cell transplantation and chimeric antigen receptor T-cell therapy. Furthermore, we examine the mechanisms through which antibiotics affect cellular therapy, the future implications of this knowledge, and the areas that warrant further investigation.
抗生素会破坏人类微生物群中细菌、真菌和病毒之间的微妙平衡。越来越多的证据表明肠道微生物群与细胞治疗之间存在重要关联，这与微生物群对免疫反应的既定影响相一致。在研究细胞治疗与微生物群之间的联系时，了解微生物群的破坏，尤其是抗生素引起的破坏如何影响这些治疗至关重要。在此，我们讨论抗生素对肠道微生物群、细胞治疗结果及相关毒性的影响，特别是在造血细胞移植和嵌合抗原受体T细胞治疗的背景下。此外，我们研究抗生素影响细胞治疗的机制、这一知识的未来意义以及值得进一步研究的领域。
