改善脑积水治疗效果的非侵入性疗法的研究重点。

Research priorities for non-invasive therapies to improve hydrocephalus outcomes.

作者信息

Hochstetler Alexandra, Hehnly Christine, Dawes William, Harris Daniel, Sadegh Cameron, Mangano Francesco T, Lanjewar Samantha N, Chau Monica J

机构信息

Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

出版信息

Fluids Barriers CNS. 2025 Mar 3;22(1):24. doi: 10.1186/s12987-025-00632-1.

DOI:10.1186/s12987-025-00632-1

PMID:40033423

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11877769/

Abstract

The Hydrocephalus Association organized two workshops with the support of the Rudi Schulte Research Institute and Cincinnati Children's Hospital Medical Center entitled "Developing Non-Invasive Hydrocephalus Therapies: Molecular and Cellular Targets", held September 27-29, 2023, in Dallas, TX, and "Developing Non-Invasive Hydrocephalus Therapies: Advancing Towards Clinical Trials", held April 12-13, 2024, in Cincinnati, OH. The goal of these workshops was to explore the frontiers of ongoing research for non-invasive therapies for the treatment of hydrocephalus across all etiologies and to improve patient outcomes at all stages of diagnosis and management. During the consensus-building discussions throughout the research workshops, basic, translational, and clinical scientists aimed to identify the next steps to develop novel treatments for hydrocephalus. This detailed report discusses the research priorities that emerged from these workshops to inspire researchers and guide studies towards better treatment for people living with hydrocephalus.

摘要

脑积水协会在鲁迪·舒尔特研究所和辛辛那提儿童医院医疗中心的支持下，组织了两次研讨会，分别是2023年9月27日至29日在德克萨斯州达拉斯市举行的“开发非侵入性脑积水疗法：分子和细胞靶点”，以及2024年4月12日至13日在俄亥俄州辛辛那提市举行的“开发非侵入性脑积水疗法：迈向临床试验”。这些研讨会的目标是探索针对所有病因的脑积水非侵入性治疗的前沿研究，并改善诊断和管理各阶段的患者预后。在整个研究研讨会的共识构建讨论中，基础、转化和临床科学家旨在确定开发脑积水新疗法的下一步措施。本详细报告讨论了这些研讨会中出现的研究重点，以激励研究人员，并指导开展研究，为脑积水患者提供更好的治疗。