Valle-Medina Antonio, Calzada-Mendoza Claudia Camelia, Ocharan-Hernández María Esther, Jiménez-Zamarripa Carlos Alberto, Juárez-Cedillo Teresa
Laboratorio 107 señalización celular, Edificio de Graduados, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, México City, México.
Unidad de Investigación Médica en Epidemiología Clínica, Unidad Médica de Alta Especialidad "Hospital de Pediatría Dr Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, México City, México.
J Alzheimers Dis Rep. 2025 Jan 13;9:25424823241307021. doi: 10.1177/25424823241307021. eCollection 2025 Jan-Dec.
Alzheimer's disease (AD) is considered a global health issue with a high social burden due to the level of disability it causes in those who suffer from it. In the absence of a therapeutic alternative for this disease, we will follow one of the biochemical pathways involved in the development of AD, which is related to molecular chaperones. The molecules are responsible for eliminating toxins and misfolded proteins at the cerebral level. These chaperones are a set of proteins from the heat shock proteins (HSPs) family, which, among their functions, help maintain homeostasis and protect cells against stress. Various authors have described the activity of HSPs in different neurodegenerative diseases, highlighting the activity of heat shock protein 70 (HSP70) in the presence of aberrant proteins characteristic of neurodegeneration, such as amyloid-β (Aβ) and tau. The role of HSP70 in AD and other dementias lies in its mechanism, which, along with other proteins from the HSP family, has the capacity to eliminate Aβ aggregates by promoting catalytic pathways. In this review, we explore the biological role of the HSP70 protein in AD and other dementias and its potential therapeutic use.
阿尔茨海默病（AD）被认为是一个全球性的健康问题，因其给患者造成的残疾程度而带来了沉重的社会负担。在缺乏针对该疾病的治疗方法的情况下，我们将研究AD发病过程中涉及的一条生化途径，该途径与分子伴侣有关。这些分子负责在大脑层面清除毒素和错误折叠的蛋白质。这些伴侣蛋白是热休克蛋白（HSPs）家族的一组蛋白质，其功能包括帮助维持体内平衡以及保护细胞免受应激。众多作者描述了HSPs在不同神经退行性疾病中的活性，特别强调了在存在神经退行性变特征性异常蛋白质（如淀粉样β蛋白（Aβ）和tau蛋白）时热休克蛋白70（HSP70）的活性。HSP70在AD及其他痴呆症中的作用在于其机制，该机制与HSP家族的其他蛋白质一起，能够通过促进催化途径清除Aβ聚集体。在本综述中，我们探讨了HSP70蛋白在AD及其他痴呆症中的生物学作用及其潜在的治疗用途。
