Gao Lei, Wen Yazhou, Guo Kunlin, Li Renqi, Mao Mao, Feng Shanwu, Wang Xian
Department of Anesthesiology, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu, China.
IBRO Neurosci Rep. 2025 Feb 10;18:311-322. doi: 10.1016/j.ibneur.2025.02.001. eCollection 2025 Jun.
Obesity can directly lead to allodynia, increase the incidence of chronic pain, and aggravate existing pain. However, the mechanisms underlying obesity-related or obesity-induced pain are still not understood. Herein, we performed a comprehensive bibliometric analysis of obesity-related or obesity-induced pain, aiming to analyze the current trends and hot spots as well as explore the underlying mechanisms.
We searched reviews and articles on obesity-related or obesity-induced pain from 2005 to 2024 via the Web of Science Core Collection (WoSCC) database. We subsequently conducted bibliometric analysis employing WPS Office, a web-based bibliometric analysis platform (https://bibliometric.com), VOSviewer, Pajek, and CiteSpace.
In total, 347 papers were identified for bibliometric analysis. The country, institution, and journal with the greatest influence were the USA, Albert Einstein College of Medicine, and Headache, respectively. Dr. Lipton RB and Dr. Karppinen J were the top 2 influential authors on the basis of their significant number of publications and citations. The keywords for the latest burst were "inflammation," "risk," "neuropathic pain," "gene-related peptide," "knee osteoarthritis," and "validation." Notably, the article titled "The association between chronic obesity and pain" by Okifuji A received the highest number of citations as well as the strongest citation burst. He and colleagues noted a significant correlation between obesity and pain in terms of clinical manifestations, but this connection is indirect and is modulated by certain biomechanical and structural alterations linked to obesity, inflammatory agents, mood disorders, sleep disturbances, and lifestyles.
There has been a notable surge in the number of articles published in the last two decades. The investigation into neuroendocrine and neuroimmune mechanisms underlying obesity-related or obesity-induced pain is expected to be a hot spot in the coming years. A potential strategy for treating chronic obesity and pain should pay attention to particular endocrine regulators, inflammatory cytokines, or immune cells that serve as central elements or crucial signaling pathways within this regulatory system.
肥胖可直接导致痛觉过敏，增加慢性疼痛的发生率，并加重现有疼痛。然而，肥胖相关或肥胖诱发疼痛的潜在机制仍不清楚。在此，我们对肥胖相关或肥胖诱发疼痛进行了全面的文献计量分析，旨在分析当前的趋势和热点，并探索潜在机制。
我们通过科学网核心合集（WoSCC）数据库检索了2005年至2024年期间关于肥胖相关或肥胖诱发疼痛的综述和文章。随后，我们使用WPS Office、一个基于网络的文献计量分析平台（https://bibliometric.com）、VOSviewer、Pajek和CiteSpace进行文献计量分析。
总共确定了347篇论文用于文献计量分析。影响最大的国家、机构和期刊分别是美国、阿尔伯特爱因斯坦医学院和《头痛》。基于发表数量和引用次数，利普顿·R·B博士和卡尔皮宁·J博士是最具影响力的两位作者。最新爆发的关键词是“炎症”、“风险”、“神经性疼痛”、“基因相关肽”、“膝骨关节炎”和“验证”。值得注意的是，冲藤彰撰写的题为《慢性肥胖与疼痛之间的关联》的文章获得了最高的引用次数以及最强的引用爆发。他和同事指出，肥胖与疼痛在临床表现方面存在显著相关性，但这种联系是间接的，并且受到与肥胖、炎症介质、情绪障碍、睡眠障碍和生活方式相关的某些生物力学和结构改变的调节。
在过去二十年中，发表的文章数量显著增加。对肥胖相关或肥胖诱发疼痛的神经内分泌和神经免疫机制的研究有望在未来几年成为一个热点。治疗慢性肥胖和疼痛的潜在策略应关注作为该调节系统核心要素或关键信号通路的特定内分泌调节因子、炎症细胞因子或免疫细胞。
