Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
J Neuroimmunol. 2010 Apr 15;221(1-2):7-14. doi: 10.1016/j.jneuroim.2009.10.015.
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous clinical presentations and course. MS is considered to be a T cell mediated disease but in recent years contribution of innate immune cells in mediating MS pathogenesis is being appreciated. In this review, we have discussed the role of various innate immune cells in mediating MS. In particular, we have provided an overview of potential anti-inflammatory or pro-inflammatory function of DCs, microglial Cells, NK cells, NK-T cells and gamma delta T cells along with their interaction among themselves and with myelin. Given the understanding of the role of the innate immune cells in MS, it is possible that immunotherapeutic intervention targeting these cells may provide a better and effective treatment.
多发性硬化症（MS）是一种慢性炎症性自身免疫性疾病，具有异质的临床表现和病程。MS 被认为是一种 T 细胞介导的疾病，但近年来，先天免疫细胞在介导 MS 发病机制中的作用受到了重视。在这篇综述中，我们讨论了各种先天免疫细胞在介导 MS 中的作用。特别是，我们提供了一个关于 DC、小胶质细胞、NK 细胞、NK-T 细胞和γδ T 细胞的潜在抗炎或促炎功能的概述，以及它们之间的相互作用及其与髓鞘的相互作用。鉴于先天免疫细胞在 MS 中的作用，针对这些细胞的免疫治疗干预可能提供更好、更有效的治疗方法。
