Martindale Robert G, Evans David C, Waitzberg Dan, Warren Malissa, Mundi Manpreet S, Klek Stanislaw, Wischmeyer Paul E, Rosenthal Martin D
Department of Surgery, Oregon Health and Science University, Portland, OR, United States.
Nutrition Support Service, OhioHealth, Columbus, OH, United States.
Front Nutr. 2025 Feb 17;12:1546089. doi: 10.3389/fnut.2025.1546089. eCollection 2025.
The International Lipids in Parenteral Nutrition (PN) Summit was convened to offer practical guidance and expert consensus opinion regarding the use of intravenous lipid emulsions (ILEs) in various clinical settings. Herein, we briefly review aspects from this summit that are of particular importance for surgical/hospitalized patients.
Summit participants identified and discussed new evidence, data, and analyses, that potentially influence the benefits and risks of ILEs in PN or their use in clinical practice. The summit meeting consisted of expert presentations that assessed recent clinical data and best practice, followed by periodic panel discussions to formulate consensus statements. Consensus statements were voted on, anonymously, by the meeting attendees.
This review briefly summarizes the rationale for considering ILE choice as a central component of any PN strategy for surgical/hospitalized patients. Thereafter, special patient populations are considered, such as surgery-related intestinal failure, major trauma, and those with chronic critical illnesses. Expert consensus statements are also provided to help bridge the gaps between evidence and clinical practice, hence complementing formal PN societal guideline recommendations.
The choice of ILE in PN, particularly those containing fish oil, can play a vital role in improving outcomes for surgical patients.
召开国际肠外营养(PN)脂质峰会,旨在就静脉脂肪乳剂(ILEs)在各种临床环境中的使用提供实用指导和专家共识意见。在此,我们简要回顾本次峰会中对手术/住院患者尤为重要的一些方面。
峰会参与者识别并讨论了可能影响ILEs在PN中的益处和风险或其在临床实践中使用的新证据、数据及分析。峰会由专家报告组成,这些报告评估了近期临床数据和最佳实践,随后进行定期小组讨论以制定共识声明。共识声明由会议参与者匿名投票表决。
本综述简要总结了将ILEs选择视为手术/住院患者任何PN策略核心组成部分的基本原理。此后,考虑了特殊患者群体,如手术相关的肠衰竭、重大创伤以及患有慢性危重病的患者。还提供了专家共识声明,以弥合证据与临床实践之间的差距,从而补充正式的PN协会指南建议。
PN中ILEs的选择,尤其是含鱼油的ILEs,对改善手术患者的预后可起到至关重要的作用。