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用于检测水中铅的比色传感器：使用巯基乙酸共轭金纳米颗粒。

Colorimetric sensor for Pb detection in water using thioglycolic acid-conjugated gold nanoparticles.

作者信息

Saputri Febrina Amelia, Aulia Talitha Shabirah, Jatmika Catur, Iswandana Raditya, Megantara Sandra, Dhumale Vinayak A

机构信息

Laboratory of Pharmaceutical-Medicinal Chemistry and Bioanalysis, Faculty of Pharmacy, Universitas Indonesia Depok 16424 Indonesia

Laboratory of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Indonesia Depok 16424 Indonesia.

出版信息

RSC Adv. 2025 Mar 3;15(9):6931-6937. doi: 10.1039/d4ra06260d. eCollection 2025 Feb 26.

DOI:10.1039/d4ra06260d
PMID:40035007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11875111/
Abstract

Environmental pollution by the heavy metal lead (Pb) poses significant health risks, including kidney damage and neurotoxicity in children. Gold nanoparticles (AuNPs) have shown promise as colorimetric sensors for visually detecting Pb through surface plasmon resonance. This study developed a colorimetric method using thioglycolic acid (TGA) as a conjugate, leveraging its strong S-Au bond and carboxyl group to enhance AuNPs stability and Pb specificity. The method was optimized and examined using UV-visible spectrophotometry, High-Resolution Transmission Electron Microscopy (HRTEM), and Fourier Transform Infrared Spectroscopy (FTIR). Optimal conditions were identified as 700 μL AuNPs, 500 μM thioglycolic acid, and pH 10.0 for 10 minutes. The synthesized TGA-AuNPs could detect Pb at a limit of 9.5 μg mL. The sensor demonstrated specificity to Pb against Ba, Mn, Cu, Mg, and Hg. The application to water samples from Lake Kenanga, Puspa, and FMIPA in Universitas Indonesia indicated that Pb levels were below the detectable concentration. This research successfully developed a simple, fast, cost-effective TGA-AuNPs colorimetric sensor for real-time Pb detection in water.

摘要

重金属铅（Pb）造成的环境污染带来了重大健康风险，包括对儿童的肾脏损害和神经毒性。金纳米颗粒（AuNPs）作为通过表面等离子体共振进行可视化检测铅的比色传感器已显示出应用前景。本研究开发了一种使用巯基乙酸（TGA）作为共轭物的比色法，利用其强大的S-Au键和羧基来提高AuNPs的稳定性和对铅的特异性。该方法使用紫外可见分光光度法、高分辨率透射电子显微镜（HRTEM）和傅里叶变换红外光谱（FTIR）进行了优化和检测。确定最佳条件为700 μL AuNPs、500 μM巯基乙酸和pH 10.0，反应10分钟。合成的TGA-AuNPs对铅的检测限为9.5 μg/mL。该传感器对铅相对于钡、锰、铜、镁和汞具有特异性。对印度尼西亚大学肯南加湖、普斯帕湖和FMIPA水样的应用表明，铅含量低于可检测浓度。本研究成功开发了一种简单、快速、经济高效的TGA-AuNPs比色传感器，用于水中铅的实时检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/d9e8414b5015/d4ra06260d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/4276b8fe8874/d4ra06260d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/fd7e5b456a36/d4ra06260d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/501bd2cb51de/d4ra06260d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/792431427c8d/d4ra06260d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/d9e8414b5015/d4ra06260d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/4276b8fe8874/d4ra06260d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/fd7e5b456a36/d4ra06260d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/501bd2cb51de/d4ra06260d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/792431427c8d/d4ra06260d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd25/11875111/d9e8414b5015/d4ra06260d-f5.jpg

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