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Long-term impact of obesity: Unraveling adipose epigenetic memory.

作者信息

Hinte Laura C, Castellano-Castillo Daniel, von Meyenn Ferdinand

机构信息

Department of Health Sciences and Technology, Laboratory of Nutrition and Metabolic Epigenetics, Institute of Food, Nutrition and Health, Zurich, Switzerland.

Department of Medical Oncology, Virgen de la Victoria University Hospital, Málaga Biomedical Research Institute (IBIMA)-CIMES-UMA, Málaga, Spain.

出版信息

Clin Transl Med. 2025 Mar;15(3):e70254. doi: 10.1002/ctm2.70254.

DOI:10.1002/ctm2.70254
PMID:40035115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11876844/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11876844/9291b87f3ba1/CTM2-15-e70254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11876844/9291b87f3ba1/CTM2-15-e70254-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee2/11876844/9291b87f3ba1/CTM2-15-e70254-g001.jpg

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本文引用的文献

1
Adipose tissue retains an epigenetic memory of obesity after weight loss.减肥后，脂肪组织保留了肥胖的表观遗传记忆。
Nature. 2024 Dec;636(8042):457-465. doi: 10.1038/s41586-024-08165-7. Epub 2024 Nov 18.
2
Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.全球范围内 1990 年至 2022 年体重不足和肥胖趋势：对 3663 项具有 2.22 亿儿童、青少年和成年人代表性的人群研究进行的汇总分析。
Lancet. 2024 Mar 16;403(10431):1027-1050. doi: 10.1016/S0140-6736(23)02750-2. Epub 2024 Feb 29.
3
Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition.
孤核组学研究揭示了具有不同可卡因成瘾样行为的杂交大鼠杏仁核 GABA 能抑制的变化。
Nat Neurosci. 2023 Nov;26(11):1868-1879. doi: 10.1038/s41593-023-01452-y. Epub 2023 Oct 5.
4
A synaptic amplifier of hunger for regaining body weight in the hypothalamus.下丘脑中恢复体重的饥饿突触放大器。
Cell Metab. 2023 May 2;35(5):770-785.e5. doi: 10.1016/j.cmet.2023.03.002. Epub 2023 Mar 24.
5
Past history of obesity triggers persistent epigenetic changes in innate immunity and exacerbates neuroinflammation.肥胖既往史会引发先天性免疫中持续的表观遗传变化，并加剧神经炎症。
Science. 2023 Jan 6;379(6627):45-62. doi: 10.1126/science.abj8894. Epub 2023 Jan 5.
6
Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity.单细胞分析血管内皮细胞揭示肥胖过程中器官特异性脆弱性的进展。
Nat Metab. 2022 Nov;4(11):1591-1610. doi: 10.1038/s42255-022-00674-x. Epub 2022 Nov 18.
7
Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice.多组学揭示了肥胖相关免疫细胞表型在小鼠减肥和体重反弹过程中在脂肪组织中的持续存在。
Nat Commun. 2022 May 26;13(1):2950. doi: 10.1038/s41467-022-30646-4.
8
Physiological and Epigenetic Features of Yoyo Dieting and Weight Control.溜溜球节食与体重控制的生理和表观遗传特征
Front Genet. 2019 Dec 11;10:1015. doi: 10.3389/fgene.2019.01015. eCollection 2019.
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