Li Yiwei, Song Shibo, Song Jin, Gong Rui, Abbas Ghulam
Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China.
Endoscopy Center, Peking University First Hospital, Beijing 100034, China.
ACS Sens. 2025 Mar 28;10(3):1690-1708. doi: 10.1021/acssensors.4c03408. Epub 2025 Mar 4.
Nonhealing chronic wounds pose severe physiological and psychological distress to patients, making them a significant concern for global public health. Effective wound management strategies assisted by smart wearable pH monitoring have the potential to substantially alleviate both social and economic burdens. The pH of the wound exudate serves as a valuable indicator for predicting infections and assessing the healing status of wounds. This review comprehensively summarizes fundamental aspects related to wound pH, with a particular emphasis on the relationships between pH and healing status, infections, and other biochemical parameters that are crucial for wound health. It systematically discusses advancements in electrochemical pH sensors specifically designed for wearable devices, emphasizing their core performance in the care of chronic wounds. Additionally, the review outlines the challenges faced by this field and suggests future directions for research and development.
难愈合的慢性伤口给患者带来了严重的生理和心理困扰,使其成为全球公共卫生领域的重大关切。借助智能可穿戴pH监测辅助的有效伤口管理策略,有可能大幅减轻社会和经济负担。伤口渗出液的pH值是预测感染和评估伤口愈合状态的重要指标。本综述全面总结了与伤口pH值相关的基本方面,特别强调了pH值与愈合状态、感染以及对伤口健康至关重要的其他生化参数之间的关系。它系统地讨论了专门为可穿戴设备设计的电化学pH传感器的进展,强调了它们在慢性伤口护理中的核心性能。此外,该综述概述了该领域面临的挑战,并提出了未来的研发方向。