Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA.
Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA; Department of Biomedical Engineering, Michigan State University, East Lansing, MI, USA.
Biosens Bioelectron. 2017 Dec 15;98:189-194. doi: 10.1016/j.bios.2017.06.053. Epub 2017 Jun 28.
Electrochemical sensors are an attractive platform for analytical measurements due to their high sensitivity, portability and fast response time. These attributes also make electrochemical sensors well suited for wearable applications which require excellent flexibility and durability. Towards this end, we have developed a robust electrochemical sensor on gauze via a unique embroidery fabrication process for quantitative measurements of wound biomarkers. For proof of principle, this biosensor was used to detect uric acid, a biomarker for wound severity and healing, in simulated wound fluid which exhibits high specificity, good linearly from 0 to 800µM, and excellent reproducibility. Continuous sensing of uric acid was also performed using this biosensor which reveals that it can generate consistent and accurate measurements for up to 7h. Experiments to evaluate the robustness of the embroidered gauze sensor demonstrate that it offers excellent resilience against mechanical stress and deformation, making it a promising wearable platform for assessing and monitoring wound status in situ.
电化学传感器因其高灵敏度、便携性和快速响应时间而成为分析测量的热门平台。这些特性也使电化学传感器非常适合需要出色的灵活性和耐用性的可穿戴应用。为此，我们通过独特的刺绣制造工艺在纱布上开发了一种强大的电化学传感器，用于定量测量伤口生物标志物。作为原理验证，该生物传感器用于检测尿酸，尿酸是伤口严重程度和愈合的生物标志物，在模拟伤口液中表现出高特异性、良好的线性度（0 到 800µM）和出色的重现性。还使用该生物传感器进行了连续的尿酸感应，结果表明它可以持续进行长达 7 小时的一致且准确的测量。评估刺绣纱布传感器稳健性的实验表明，它具有出色的抗机械应力和变形能力，使其成为评估和原位监测伤口状况的有前途的可穿戴平台。
