Pedersoli W M, Fazeli M H, Haddad N S, Ravis W R, Carson R L
Am J Vet Res. 1985 May;46(5):1025-8.
Endometrial tissue and blood serum gentamicin (GT) concentrations were determined in 6 ovariectomized pony mares given intrauterine infusions (50 ml of a 5% commercial aqueous solution of GT) each day for 5 consecutive days. The mares were subjected to the following 3 treatments: (1) GT infusion only (trial A, control); (2) progesterone plus GT (trial B, P + G); and (3) estradiol plus GT (trial C, E + G). Endometrial tissue concentrations of GT (micrograms/g) at 24 and 120 hours were significantly higher (P less than 0.05) in trials B (65.54 +/- 15.57 and 100.33 +/- 19.27) and C (73.33 +/- 22.53 and 74.09 +/- 8.60) than in trial A (4.23 +/- 0.70). Endometrial concentration for trial A at 120 hours was also significantly higher than trial A at 24 hours. There was no significant difference (P greater than 0.05) in endometrial concentrations among trials A, B, and C at 120 hours. Serum GT concentrations were significantly lower than endometrial tissue concentrations. The highest serum concentrations of GT found in every trial occurred at 6 hours after each intrauterine infusion of GT. The highest overall serum concentration of GT (micrograms/ml) determined occurred in trial B (8.30 +/- 1.28) at 78 hours. There was no significant difference in serum concentrations of GT between days of treatment, except for trial A at 78 and 102 hours, respectively. Serum concentrations of GT were significantly higher (P less than 0.05) than trial A at 30, 54, 78, and 102 hours in trial B, and at 78 and 102 hours in trial C. There was no significant difference in serum concentrations of GT between trials B and C.
对6匹去卵巢的母马进行连续5天每天一次的子宫内输注（50毫升5%庆大霉素商业水溶液），并测定其子宫内膜组织和血清中的庆大霉素（GT）浓度。这些母马接受了以下3种处理：（1）仅输注GT（试验A，对照组）；（2）孕酮加GT（试验B，P + G）；（3）雌二醇加GT（试验C，E + G）。在试验B（65.54±15.57和100.33±19.27）和试验C（73.33±22.53和74.09±8.60）中，24小时和120小时时子宫内膜组织中GT的浓度（微克/克）显著高于试验A（4.23±0.70）（P<0.05）。试验A在120小时时的子宫内膜浓度也显著高于24小时时的浓度。试验A、B和C在120小时时的子宫内膜浓度之间没有显著差异（P>0.05）。血清GT浓度显著低于子宫内膜组织浓度。每次子宫内输注GT后6小时，每个试验中测得的血清GT浓度最高。在试验B中，78小时时测得的GT总体血清浓度最高（微克/毫升）（8.30±1.28）。除试验A分别在78小时和102小时外，治疗各天之间血清GT浓度没有显著差异。在试验B中，30、54、78和102小时时血清GT浓度显著高于试验A（P<0.05），在试验C中，78和102小时时血清GT浓度显著高于试验A。试验B和试验C之间血清GT浓度没有显著差异。
