Oehmichen M, Wiethölter H, Greaves M F
J Neuropathol Exp Neurol. 1979 Mar;38(2):99-103. doi: 10.1097/00005072-197903000-00002.
While it is certain that reactive microglia (phagocytes in damaged brain tissue) originate from monocytes, the derivation of resting microglia (argentophilic cells in undamaged brain tissue) is not clear. In order to examine a possible lymphocytic and/or monocytic origin for resting microglia, cryostat sections of presumably normal human brain tissue were treated with anti-lymphocyte, anti-monocyte and anti-beta 2-microglobulin sera and then stained with the immunoperoxidase technique. No positive reaction was obtained. It must be concluded that resting microglia are not derived from mononuclear blood cells.
虽然反应性小胶质细胞（受损脑组织中的吞噬细胞）确实起源于单核细胞，但静息小胶质细胞（未受损脑组织中的嗜银细胞）的来源尚不清楚。为了研究静息小胶质细胞可能的淋巴细胞和/或单核细胞起源，将推测为正常人类脑组织的冰冻切片用抗淋巴细胞、抗单核细胞和抗β2-微球蛋白血清处理，然后用免疫过氧化物酶技术染色。未获得阳性反应。必须得出结论，静息小胶质细胞并非源自单核血细胞。
