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妊娠期间的间变性节细胞胶质瘤:脑水肿及孕产妇死亡的一个原因

Anaplastic ganglioglioma in pregnancy a cause of cerebral edema and maternal death.

作者信息

Capera Luisa F, Aragón Mendoza Rafael L, Roa Roberto Gallo, Romero Viviana Dávila

机构信息

Obstetrics and Gynecology Resident, Universidad De La Sabana, Hospital Universitario de La Samaritana, Bogotá, Colombia.

Specialist in Maternal-Fetal Medicine, Hospital Universitario De La Samaritana, Bogotá, Colombia.

出版信息

Case Rep Perinat Med. 2022 Apr 7;11(1):20220002. doi: 10.1515/crpm-2022-0002. eCollection 2022 Jan.

DOI:10.1515/crpm-2022-0002
PMID:40041218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11800684/
Abstract

OBJECTIVES

The true incidence of anaplastic ganglioglioma during pregnancy is extremely rare, very few cases have been reported in the literature.

CASE PRESENTATION

This is a report of a case of anaplastic ganglioglioma diagnosed in pregnancy. The patient is a 23-year-old primigravida who presented at 19 weeks of gestation headache and a convulsive episode. Her workup revealed a rare cerebral tumor that progressed to a neurological decline and died during the postpartum period.

CONCLUSIONS

Anaplastic ganglioglioma is an aggressive counterpart of Glial tumors; in pregnancy they are rare and symptoms are nonspecific. The outcome for the mother in this case fatal and a protocol for these cases has not yet been reported.

摘要

目的

间变性节细胞胶质瘤在孕期的真实发病率极低,文献中报道的病例极少。

病例报告

本文报告一例孕期诊断为间变性节细胞胶质瘤的病例。患者为一名23岁初产妇,妊娠19周时出现头痛和惊厥发作。检查发现一个罕见的脑肿瘤,该肿瘤进展导致神经功能衰退,并在产后死亡。

结论

间变性节细胞胶质瘤是胶质瘤的侵袭性类型;在孕期罕见且症状无特异性。该病例中母亲的结局是致命的,此类病例的治疗方案尚未见报道。

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本文引用的文献

1
Cancer in pregnancy.妊娠期癌症。
Int J Gynaecol Obstet. 2018 Oct;143 Suppl 2:137-142. doi: 10.1002/ijgo.12621.
2
Magnetic resonance imaging findings of mixed neuronal-glial tumors with pathologic correlation: a review.具有病理相关性的混合性神经元-胶质肿瘤的磁共振成像表现:综述
Acta Neurol Belg. 2018 Sep;118(3):379-386. doi: 10.1007/s13760-018-0981-1. Epub 2018 Jul 9.
3
Subtotal Resection of an Anaplastic Ganglioglioma in Pregnancy.孕期间变性节细胞胶质瘤的次全切除术
Case Rep Obstet Gynecol. 2018 May 10;2018:4606354. doi: 10.1155/2018/4606354. eCollection 2018.
4
Impact of surgery, adjuvant treatment, and other prognostic factors in the management of anaplastic ganglioglioma.手术、辅助治疗及其他预后因素在间变性节细胞胶质瘤管理中的影响
Childs Nerv Syst. 2018 Jun;34(6):1207-1213. doi: 10.1007/s00381-018-3780-3. Epub 2018 Mar 29.
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Management of Skull Base Tumors in the Obstetric Population: A Case Series.产科患者颅底肿瘤的处理:病例系列研究。
World Neurosurg. 2018 May;113:e373-e382. doi: 10.1016/j.wneu.2018.02.038. Epub 2018 Feb 14.
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Management of intracranial pathology during pregnancy: Case example and review of management strategies.孕期颅内病变的管理:病例示例及管理策略综述
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Pregnancy and glial brain tumors.妊娠与胶质脑肿瘤
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Increased growth rate of a WHO grade I ganglioglioma during pregnancy.
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Pregnancy and brain tumors.妊娠与脑肿瘤。
Neurol Clin. 2012 Aug;30(3):937-46. doi: 10.1016/j.ncl.2012.04.003. Epub 2012 Jun 9.