Bicocca Matthew J, Gilbert Andrea R, Sadrameli Saeed S, Pirics Michael L
Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, TX, USA.
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Case Rep Obstet Gynecol. 2018 May 10;2018:4606354. doi: 10.1155/2018/4606354. eCollection 2018.
Anaplastic ganglioglioma is a rare malignant brain tumor associated with high morbidity and mortality. The diagnosis of a central nervous system malignancy in the early 3rd trimester presents management challenges to both neurosurgeons and obstetricians.
A 33-year-old woman, gravida 2 para 1, presented at 28 6/7 weeks with four months of worsening headaches, nausea, vomiting, and mental status changes due to a 7.5 cm anaplastic ganglioglioma. Maternal deterioration necessitated subtotal tumor debulking allowing prolongation of the gestation to 34 6/7 weeks. After delivery, the patient underwent further resection, followed by chemotherapy and radiation. Both mother and infant are well.
This case underscores the importance of timely diagnostic imaging in pregnant women and demonstrates subtotal tumor debulking as a viable means of prolonging gestation.
间变性节细胞胶质瘤是一种罕见的恶性脑肿瘤，发病率和死亡率都很高。孕晚期早期诊断出中枢神经系统恶性肿瘤给神经外科医生和产科医生都带来了管理挑战。
一名33岁女性，孕2产1，孕28 6/7周时因7.5厘米间变性节细胞胶质瘤出现四个月来不断加重的头痛、恶心、呕吐及精神状态改变。母亲病情恶化，需要进行肿瘤次全切除以将孕周延长至34 6/7周。分娩后，患者接受了进一步切除，随后进行化疗和放疗。母婴均状况良好。
该病例强调了对孕妇进行及时诊断性成像的重要性，并证明肿瘤次全切除是延长孕周的一种可行方法。
