Bissette G, Nemeroff C B, Decker M W, Kizer J S, Agid Y, Javoy-Agid F
Ann Neurol. 1985 Apr;17(4):324-8. doi: 10.1002/ana.410170403.
Frozen samples of postmortem human brain tissue from patients with Parkinson's disease (n = 25) and control patients who died without neurological disease (n = 25) were assayed for neurotensin and bombesin by specific radioimmunoassay. Twelve brain regions were examined: substantia nigra, ventral tegmental area, periaqueductal gray matter, caudate nucleus, putamen, globus pallidus, amygdala, hippocampus, nucleus accumbens, frontal cortex, cingulate cortex, and entorhinal cortex. In patients with Parkinson's disease, the concentration of bombesin was significantly decreased in the caudate nucleus and globus pallidus, and the concentration of neurotensin was significantly reduced in the hippocampus. The concentration of neither peptide was significantly altered in the substantia nigra or ventral tegmental area, two regions known to exhibit reductions in other neurotransmitter substances.
通过特异性放射免疫分析法，对帕金森病患者（n = 25）和无神经疾病死亡的对照患者（n = 25）的死后人类脑组织冷冻样本进行神经降压素和蛙皮素检测。检查了十二个脑区：黑质、腹侧被盖区、导水管周围灰质、尾状核、壳核、苍白球、杏仁核、海马体、伏隔核、额叶皮质、扣带回皮质和内嗅皮质。在帕金森病患者中，尾状核和苍白球中的蛙皮素浓度显著降低，海马体中的神经降压素浓度显著降低。在黑质或腹侧被盖区这两个已知其他神经递质物质会减少的区域，两种肽的浓度均未发生显著改变。
