Ghatei M A, Bloom S R, Langevin H, McGregor G P, Lee Y C, Adrian T E, O'Shaughnessy D J, Blank M A, Uttenthal L O
Brain Res. 1984 Feb 13;293(1):101-9. doi: 10.1016/0006-8993(84)91457-4.
In order to compare within the same brains the quantitative distributions of a range of neuropeptides, bombesin, N- and C-terminal glucagon, cholecystokinin, neurotensin, somatostatin, substance P and vasoactive intestinal polypeptide immunoreactivities were determined by radioimmunoassay in 24 regions of 5 normal adult human brains. Each peptide showed a different distribution pattern. Of the peptides not previously mapped in detail in the human brain, bombesin-like immunoreactivity was present in all regions with the highest concentrations in particular areas of the hypothalamus, septal nuclei, nucleus accumbens, globus pallidus, amygdala, periaqueductal grey and substantia nigra. C- and N-terminal glucagon immunoreactivities were detected only in the ventromedial hypothalamus. The concentrations of the remaining 5 peptide immunoreactivities, and their molecular forms, were in good general agreement with those reported individually by others in both human brains and those of experimental animals. The quantitative mapping of the regulatory peptides in the human brain provides an essential base for further comparative study in diseased postmortem brains.
为了在同一大脑内比较一系列神经肽的定量分布，通过放射免疫分析法测定了5个正常成人大脑24个区域中蛙皮素、N端和C端胰高血糖素、胆囊收缩素、神经降压素、生长抑素、P物质和血管活性肠肽免疫反应性。每种肽都显示出不同的分布模式。在之前未在人脑中详细绘制图谱的肽中，蛙皮素样免疫反应性存在于所有区域，在下丘脑特定区域、隔核、伏隔核、苍白球、杏仁核、导水管周围灰质和黑质中浓度最高。C端和N端胰高血糖素免疫反应性仅在下丘脑腹内侧被检测到。其余5种肽免疫反应性的浓度及其分子形式，与其他人在人脑中以及实验动物脑中单独报道的结果总体上高度一致。人脑中调节肽的定量图谱为死后患病大脑的进一步比较研究提供了重要基础。
