Zhou Bangguo, Duan Yangying, Li Wenhao, Chen Tao, Wang Jincheng, Cao Manting, Lin Guohao, Yang Ke, Lai Zhangqi, Wu Wencheng
Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, P. R. China.
Central Laboratory and Department of Medical Ultrasound, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, P. R. China.
Adv Sci (Weinh). 2025 Apr;12(16):e2414161. doi: 10.1002/advs.202414161. Epub 2025 Mar 5.
The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation of inflammation levels, and prevention of bacterial infections. Therefore, a multifunctional wound dressing with antioxidant, local glycocontrol, and antibacterial properties is developed to promote diabetic wound healing. This dressing is constructed by co-loading gold-cerium oxide (AuCeO) dumbbells and glucose oxidase (GOx) into a reactive oxygen species (ROS)-sensitive hydrogel matrix (ACG gels). In this system, Au-CeO dumbbells effectively eliminate ROS, protecting cells from oxidative stress-induced damage while exhibiting significant near-infrared photothermal antibacterial activity. Additionally, the controlled release of GOx decreases blood glucose levels in the wound microenvironment, alleviating oxidative stress and inhibiting bacterial growth proliferation, thereby expediting the healing process. ACG gels demonstrated excellent wound healing-promoting properties in two in vivo wound models, providing a promising and effective platform for diabetic wound management.
慢性糖尿病伤口的管理是一项复杂的挑战，需要进行局部血糖调节、炎症水平调节以及预防细菌感染。因此，开发了一种具有抗氧化、局部血糖控制和抗菌特性的多功能伤口敷料，以促进糖尿病伤口愈合。这种敷料是通过将金-氧化铈（AuCeO）哑铃状颗粒和葡萄糖氧化酶（GOx）共同负载到对活性氧（ROS）敏感的水凝胶基质（ACG凝胶）中构建而成。在该系统中，Au-CeO哑铃状颗粒有效消除ROS，保护细胞免受氧化应激诱导的损伤，同时展现出显著的近红外光热抗菌活性。此外，GOx的控释降低了伤口微环境中的血糖水平，减轻氧化应激并抑制细菌生长增殖，从而加速愈合过程。ACG凝胶在两种体内伤口模型中均表现出优异的促进伤口愈合特性，为糖尿病伤口管理提供了一个有前景且有效的平台。
