Wiles J C, Hansen R C, Lynch P J
Arch Dermatol. 1985 Jun;121(6):802-5.
Cutaneous vasculitis may present as an urticaria-like eruption in association with viral illness, systemic lupus erythematosus, Sjögren's syndrome, or serum sickness. Often, however, urticarial vasculitis presents as an immune complex-mediated disease without other associated connective-tissue disease or associated infection. Many forms of therapy have been tried, including antihistamines, prednisone, and immunosuppressive drugs without success in every patient. Because colchicine had been effective in some patients with non-urticarial cutaneous vasculitis, we decided to use it in two patients with urticarial vasculitis in whom other therapy had failed. Both responded dramatically, although severe hypocomplementemia persisted in one patient.
皮肤血管炎可能表现为与病毒感染、系统性红斑狼疮、干燥综合征或血清病相关的荨麻疹样皮疹。然而，荨麻疹性血管炎通常表现为一种免疫复合物介导的疾病，无其他相关结缔组织病或相关感染。人们尝试了多种治疗方法，包括使用抗组胺药、泼尼松和免疫抑制药物，但并非对每个患者都有效。由于秋水仙碱对一些非荨麻疹性皮肤血管炎患者有效，我们决定将其用于两名其他治疗方法均失败的荨麻疹性血管炎患者。两名患者均有显著反应，尽管其中一名患者仍持续存在严重补体低下。
