Friedman Jeffrey M
Rockefeller University and Howard Hughes Medical Institute, New York, NY, USA.
Cell Metab. 2025 Mar 4;37(3):570-577. doi: 10.1016/j.cmet.2025.01.026.
Over the last 30 years, our understanding of the causes of obesity has been transformed, and new, highly effective medicines for reducing weight have been developed. This remarkable progress marks an end and a beginning. By establishing that obesity is a biologic disorder amenable to scientific inquiry and rational drug development, simplistic notions about its causes and treatment should be laid to rest. The future holds the promise that additional therapeutic approaches for inducing or maintaining weight loss will be developed, and that these treatments will be tailored to different subgroups to potentially address the pathogenic mechanisms.
在过去30年里，我们对肥胖成因的理解发生了转变，并且已经研发出了新的、高效的减肥药物。这一显著进展标志着一个结束和一个开始。通过确定肥胖是一种可通过科学探究和合理药物研发来解决的生物紊乱问题，关于其成因和治疗的简单化观念应该被摒弃。未来有望开发出更多诱导或维持体重减轻的治疗方法，并且这些治疗方法将针对不同亚组进行定制，以潜在地解决致病机制。
