Claflin Kristin E, Potthoff Matthew J
Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, Iowa.
Department of Veterans Affairs Medical Center, Oklahoma City, Oklahoma; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma.
Cell Mol Gastroenterol Hepatol. 2025 May 8;19(8):101531. doi: 10.1016/j.jcmgh.2025.101531.
Metabolic homeostasis is maintained through a delicate balance of communication within and between multiple organ systems. These communication networks are essential for regulating nutrient intake, utilization, and storage. Conditions of metabolic dysfunction can impair proper tissue communication, which contributes to the progression of metabolic disease including obesity, hepatic steatosis, and type II diabetes. In this collection of Cellular and Molecular Gastroenterology and Hepatology, we highlight new advances in transcellular and interorgan communication, particularly in the liver and gastrointestinal (GI) tract, and how impairments in these biologic networks contribute to metabolic disease. In addition, we emphasize the therapeutic potential for modulating these communication pathways to treat metabolic disease.
代谢稳态通过多个器官系统内部以及它们之间精细的沟通平衡得以维持。这些沟通网络对于调节营养物质的摄入、利用和储存至关重要。代谢功能障碍的情况会损害正常的组织间沟通，进而促使包括肥胖、肝脂肪变性和II型糖尿病在内的代谢性疾病的发展。在这本《细胞与分子胃肠病学和肝病学》论文集中，我们重点介绍了跨细胞和器官间沟通方面的新进展，特别是在肝脏和胃肠道方面，以及这些生物网络中的损伤如何导致代谢性疾病。此外，我们强调了调节这些沟通途径以治疗代谢性疾病的治疗潜力。
