Golledge Jonathan, Venn Alkira, Leicht Anthony, Burton Nicola, Parmenter Belinda, Moxon Joseph V
Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University.
The Department of Vascular and Endovascular Surgery, Townsville University Hospital.
J Atheroscler Thromb. 2025 Sep 1;32(9):1101-1108. doi: 10.5551/jat.65531. Epub 2025 Mar 5.
This post-hoc analysis from the Behavioural Intervention by allied health professionals to promote Physical activity (BIP) trial examined the relationship between depression and step count and walking capacity over two years in people with peripheral artery disease (PAD).
BIP included participants with walking impairment due to PAD followed up at 4, 12 and 24 months to measure step count over 7 days using an accelerometer and six-minute walking distance. The relationships between depression at entry with step count and walking distance during follow-up were assessed using linear mixed effects models.
At entry, 29 (14.5%) of the 200 participants had depression being treated with anti-depressant medication. Participants diagnosed with depression were more likely to be female (13 of 29, 44.8%) than those not diagnosed with depression (43 of 171, 25.1%). Over 24 months follow-up, daily step count progressively decreased in participants with depression (mean [SD] 4406 (2266) at entry to 3888 (2555) at 24 months) as compared to no change in participants without depression (mean (SD) 5271 (2526) at entry compared to 5120 (2446) at 24 months), inter-group difference p = 0.010. No significant difference in change in six-minute walking distance over 2 years was found between participants with and those without depression.
Depression is associated with greater decline in self-regulated walking in patients with PAD. Effective treatments for depression are needed which help promote physical activity in people with PAD.
本项来自联合健康专业人员行为干预促进身体活动（BIP）试验的事后分析，研究了外周动脉疾病（PAD）患者在两年内抑郁与步数及步行能力之间的关系。
BIP纳入了因PAD导致行走障碍的参与者，在4个月、12个月和24个月进行随访，使用加速度计测量7天的步数，并测量六分钟步行距离。使用线性混合效应模型评估入组时的抑郁与随访期间步数和步行距离之间的关系。
入组时，200名参与者中有29名（14.5%）正在使用抗抑郁药物治疗抑郁症。被诊断为抑郁症的参与者中女性比例（29名中的13名，44.8%）高于未被诊断为抑郁症的参与者（171名中的43名，25.1%）。在24个月的随访中，抑郁症患者的每日步数逐渐减少（入组时平均[标准差]为4406（2266），24个月时为3888（2555）），而无抑郁症参与者的步数没有变化（入组时平均（标准差）为5271（2526），24个月时为5120（2446）），组间差异p = 0.010。在2年的六分钟步行距离变化方面，抑郁症患者与无抑郁症患者之间未发现显著差异。
抑郁症与PAD患者自我调节步行能力的更大下降有关。需要有效的抑郁症治疗方法，以帮助促进PAD患者的身体活动。
