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成人右心超声心动图评估指南及肺动脉高压的特殊考量:美国超声心动图学会的建议

Guidelines for the Echocardiographic Assessment of the Right Heart in Adults and Special Considerations in Pulmonary Hypertension: Recommendations from the American Society of Echocardiography.

作者信息

Mukherjee Monica, Rudski Lawrence G, Addetia Karima, Afilalo Jonathan, D'Alto Michele, Freed Benjamin H, Friend Lynsy B, Gargani Luna, Grapsa Julia, Hassoun Paul M, Hua Lanqi, Kim Jiwon, Mercurio Valentina, Saggar Rajan, Vonk-Noordegraaf Anton

机构信息

Johns Hopkins University School of Medicine, Baltimore, Maryland.

Division of Cardiology, Azrieli Heart Center, Jewish General Hospital, McGill University, Montreal, Quebec, Canada.

出版信息

J Am Soc Echocardiogr. 2025 Mar;38(3):141-186. doi: 10.1016/j.echo.2025.01.006.

Abstract

Right heart adaptation to pulmonary hypertension (PH) is a critical determinant of clinical outcomes, morbidity, and mortality in patients with or at risk for cardiopulmonary disease. The World Symposium on Pulmonary Hypertension recently redefined PH as a mean pulmonary arterial pressure >20 mm Hg, based on a wealth of epidemiologic evidence underscoring the significant impact of even mildly elevated mean pulmonary artery pressures on major adverse clinical events. The lowered diagnostic threshold for PH has renewed interest in echocardiography and its critical role in early detection and screening, refined hemodynamic evaluation, and longitudinal monitoring. However, the systematic assessment of the right heart remains inconsistent, largely due to the predominant focus on left heart evaluation, limited familiarity with right heart ultrasound techniques, and a paucity of reference data defining normal right heart size and function. A systematic, comprehensive ultrasound-based assessment of the right heart offers valuable diagnostic insights for in screening at-risk populations, PH classification, risk stratification, monitoring therapeutic response, and informing prognostication, thereby improving clinical outcomes.

摘要

右心对肺动脉高压(PH)的适应性是心肺疾病患者或有患心肺疾病风险患者临床结局、发病率和死亡率的关键决定因素。基于大量流行病学证据强调即使轻度升高的平均肺动脉压对主要不良临床事件也有重大影响,世界肺动脉高压研讨会最近将PH重新定义为平均肺动脉压>20 mmHg。PH诊断阈值的降低重新引发了对超声心动图及其在早期检测和筛查、精确血流动力学评估以及纵向监测中的关键作用的兴趣。然而,对右心的系统评估仍然不一致,这主要是由于主要关注左心评估、对右心超声技术的熟悉程度有限以及缺乏定义正常右心大小和功能的参考数据。基于超声的对右心进行系统、全面的评估可为筛查高危人群、PH分类、风险分层、监测治疗反应和提供预后信息提供有价值的诊断见解,从而改善临床结局。

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