Dobbing J, Sands J
Arch Fr Pediatr. 1985 Mar;42(3):199-203.
The development of tissues and organs in the post-embryogenic period has commonly been thought to be by two main consecutive processes: the multiplication of cells followed by a growth in their size. The capacity for recovery following growth restriction has been considered to depend on whether restriction occurred during the phase of cell multiplication, in which case catch-up was permanently inhibited; or later, in which case recovery could occur. This model is now no longer valid for a number of reasons, the main one being that the original assumptions about the sequence of developmental processes have been shown to be false. There certainly seems to be an early period of vulnerability during which restriction is not followed by catch-up, but this cannot now be related to the multiplication of cells.
细胞增殖，随后是细胞大小的增长。生长受限后的恢复能力被认为取决于限制是发生在细胞增殖阶段，在这种情况下追赶生长会被永久抑制；还是发生在后期，在这种情况下可以恢复。由于多种原因，这个模型现在不再有效，主要原因是关于发育过程顺序的原始假设已被证明是错误的。确实似乎存在一个早期易损期，在此期间限制后不会出现追赶生长，但这现在与细胞增殖无关。
