Kossmann J C, Ribon B, Claris O, Brazier J L, Salle B
Arch Fr Pediatr. 1985 Apr;42(4):317-20.
A lyophilized preparation of phenobarbital was studied in newborns without cerebral palsy. Plasma levels were determined using gas chromatograph fitted with thermo ionic probe after either an intra-muscular (IM) injection in premature infants or an intravenous (IV) injection over single dose of phenobarbital 10 mg/kg within 6 hours after birth. Five term babies were included in the study as controls and received an IM injection. The results showed rapid increase in plasma concentration after IM injection in 10 of 13 subjects with a peak concentration reached 60 minutes after injection. The mean ratio (maximal concentration/dose) was 1.25 and 1.10 for term infants and preterm infants respectively. In all cases, the drug was well tolerated. In 15 preterm infants (n: 7 IM and n: 8 IV) the plasma concentrations were followed over a period of 15 days. The disappearance curve was biphasic; it varied the first 7 days, then remained constant for the following week (apparent half life 106 hours).
对未患脑瘫的新生儿使用苯巴比妥冻干制剂进行了研究。在早产儿进行肌内注射（IM）或出生后6小时内静脉注射（IV）单剂量10mg/kg苯巴比妥后，使用配备热离子探针的气相色谱仪测定血浆水平。5名足月儿作为对照纳入研究并接受肌内注射。结果显示，13名受试者中有10名在肌内注射后血浆浓度迅速升高，注射后60分钟达到峰值浓度。足月儿和早产儿的平均比值（最大浓度/剂量）分别为1.25和1.10。在所有病例中，药物耐受性良好。在15名早产儿（7名肌内注射，8名静脉注射）中，对血浆浓度进行了15天的跟踪监测。消失曲线呈双相性；在最初7天有所变化，随后一周保持恒定（表观半衰期106小时）。
