Dutra Tauane A, Fragoso Marilene B T, Wanderley Thiago M, Bezerra Alexandra R, Bueno Nassib B, de Oliveira Alane C M
Programa de Pós-Graduação em Nutrição, Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, Alagoas, 57.072-970, Brazil.
Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Maceió, Alagoas, 57.072-970, Brazil.
Br J Nutr. 2025 Jun 14;133(11):1404-1417. doi: 10.1017/S0007114525000443. Epub 2025 Mar 6.
The primary causes of female mortality often involve diseases related to oxidative stress. Dietary total antioxidant capacity (TAC) evaluates its antioxidant content and potential health effects. This study, registered with PROSPERO (ID: CRD42024427784), explores the association between dietary TAC and women’s health outcomes, including endocrine conditions with gynaecological implications, obstetric outcomes, gynaecological conditions and oncological diseases related to the female reproductive system. We conducted a systematic search in MEDLINE (via PubMed), EMBASE, LILACS and CINAHL for observational studies published up to February 2024 that explored the relationship between dietary TAC and these health conditions. Data were analysed using RevMan 5·4 software. Nineteen studies met the eligibility criteria (sample sizes: 64–3209 women) and examined various conditions, including neoplasms (breast, endometrial and ovarian), bacterial vaginosis, menopause, polycystic ovary syndrome (PCOS), pre-eclampsia (PE), gestational diabetes mellitus (GDM), miscarriage, infertility and inflammation and oxidative stress markers. The meta-analysis identified a significant association between dietary TAC, measured in vitamin C equivalents, and breast cancer, revealing that women with the disease had a lower dietary TAC due to reduced antioxidant intake. Mixed results were found for endometrial cancer, while higher TAC levels were associated with a lower risk of PCOS and infertility. Among postmenopausal women, higher TAC correlated with fewer symptoms such as sleep issues and anxiety. In gestational conditions, higher dietary TAC was linked to a lower risk of miscarriage, GDM and PE. Twelve of the nineteen studies demonstrated significant associations between dietary TAC and the outcomes of interest.
女性死亡的主要原因通常涉及与氧化应激相关的疾病。膳食总抗氧化能力（TAC）评估其抗氧化剂含量及潜在的健康影响。本研究已在国际前瞻性系统评价注册库（PROSPERO，编号：CRD42024427784）登记，探讨膳食TAC与女性健康结局之间的关联，这些结局包括具有妇科意义的内分泌疾病、产科结局、妇科疾病以及与女性生殖系统相关的肿瘤疾病。我们在MEDLINE（通过PubMed）、EMBASE、拉丁美洲及加勒比地区健康科学数据库（LILACS）和护理学与健康领域数据库（CINAHL）中进行了系统检索，以查找截至2024年2月发表的观察性研究，这些研究探讨了膳食TAC与上述健康状况之间的关系。使用RevMan 5·4软件对数据进行分析。19项研究符合纳入标准（样本量：64 - 3209名女性），并考察了多种状况，包括肿瘤（乳腺癌、子宫内膜癌和卵巢癌）、细菌性阴道病、绝经、多囊卵巢综合征（PCOS）、先兆子痫（PE）、妊娠期糖尿病（GDM）、流产、不孕症以及炎症和氧化应激标志物。荟萃分析确定，以维生素C当量衡量的膳食TAC与乳腺癌之间存在显著关联，表明患有该疾病的女性由于抗氧化剂摄入量减少，其膳食TAC较低。子宫内膜癌的结果不一，而较高的TAC水平与较低的PCOS和不孕症风险相关。在绝经后女性中，较高的TAC与较少的睡眠问题和焦虑等症状相关。在妊娠期，较高的膳食TAC与较低的流产、GDM和PE风险相关。19项研究中有12项表明膳食TAC与相关结局之间存在显著关联。
