Medvedev N Iu
Arkh Patol. 1985;47(4):42-7.
Adrenal glands of 52 children dying from a syndrome of sudden death (SSD) and 14 children of the same age dying from acute viral respiratory infections (AVRI) with a long terminal period were studied. The following adrenal changes typical for the SSD were observed: low weight, decrease of the size of the definitive cortex and its zones, the appearance of numerous adenomatous growths in the definitive cortex and so-called giant cells in the fetal cortex, low secretory activity. The appearance of adenomas and giant cells in the presence of organ hypoplasia is a compensatory-hyperplastic adrenal response which attests to a long glucocorticoid deficiency in the SSD. It is suggested that the deficiency of these hormones leads to the metabolic disturbances in various organs, including brain, resulting in the narrowing of the range of homeostatic host responses; this may become the cause of sudden death when the clinical and morphological manifestations of AVRI are insignificant.
对52名死于猝死综合征（SSD）的儿童以及14名死于急性病毒性呼吸道感染（AVRI）且终末期较长的同龄儿童的肾上腺进行了研究。观察到以下SSD典型的肾上腺变化：重量减轻、成熟皮质及其各带大小减小、成熟皮质中出现大量腺瘤样增生以及胎儿皮质中出现所谓的巨细胞、分泌活性降低。在器官发育不全的情况下出现腺瘤和巨细胞是肾上腺的代偿性增生反应，这证明了SSD中存在长期糖皮质激素缺乏。提示这些激素的缺乏会导致包括脑在内的各种器官的代谢紊乱，导致体内稳态宿主反应范围变窄；当AVRI的临床和形态学表现不明显时，这可能成为猝死的原因。
