Liao Wan-Zhe, Wang Jia-He, Zhong Hua-Jie, Wen Shen-Yu, Chen Yang, Chen Jia-Qi, Zhang Xue-Kun, Wu Xin-Yi, Tan Jia-Nuo, Li Kun-Yi, Mo Shao-Cong, Wang Li-Jun
Nanshan College of Guangzhou Medical University, Guangzhou 511436, China.
School of Stomatology, Guangzhou Medical University, Guangzhou 510182, China.
Brain Commun. 2025 Feb 5;7(2):fcaf053. doi: 10.1093/braincomms/fcaf053. eCollection 2025.
Meningioma, a prevalent central nervous system tumour, presents a significant challenge in neuro-oncology. This study harnesses genome-wide association studies (GWAS) and transcriptomic analysis to illuminate the pathological underpinnings of meningioma and spearhead the discovery of novel drug targets. By employing summary-data-based Mendelian randomization (SMR), colocalization analyses and Mendelian randomization, we pinpointed four genes as pivotal therapeutic targets. The integration of bulk and single-cell RNA sequencing confirmed the upregulated expression of three of the genes (, and ) in meningioma tissues, unravelling their cellular distribution and hinting at the tumour's intrinsic heterogeneity. Molecular docking further identified dexamethasone and levonorgestrel as potential modulators of these targets, paving the way for personalized meningioma treatment strategies. This research advances our understanding of meningioma's molecular landscape and illustrates the power of genomic and transcriptomic integration in the realm of precision oncology.
脑膜瘤是一种常见的中枢神经系统肿瘤，在神经肿瘤学中是一个重大挑战。本研究利用全基因组关联研究（GWAS）和转录组分析来阐明脑膜瘤的病理基础，并率先发现新的药物靶点。通过基于汇总数据的孟德尔随机化（SMR）、共定位分析和孟德尔随机化，我们确定了四个基因作为关键治疗靶点。批量和单细胞RNA测序的整合证实了其中三个基因（、和）在脑膜瘤组织中的表达上调，揭示了它们的细胞分布，并暗示了肿瘤的内在异质性。分子对接进一步确定地塞米松和左炔诺孕酮是这些靶点的潜在调节剂，为个性化脑膜瘤治疗策略铺平了道路。这项研究推进了我们对脑膜瘤分子格局的理解，并说明了基因组和转录组整合在精准肿瘤学领域的作用。
