Vassilopoulos Athanasios, McCormick Winston, Lakhani Alisha
Division of Infectious Diseases, Department of Medicine Warren Alpert Medical School at Brown University; Co-first author.
Warren Alpert Medical School at Brown University; Co-first author.
Brown J Hosp Med. 2022 Aug 19;1(3):37667. doi: 10.56305/001c.37667. eCollection 2022.
Elevated serum ferritin is a marker of macrophage activation and is associated with increased mortality. The hyperferritinemic syndromes which include hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS), catastrophic antiphospholipid syndrome (CAPS), septic shock, adult-onset Still's Disease (AOSD), and multi-inflammatory syndrome related to COVID-19 (MIS-C/A) are characterized by intense inflammation and its sequalae. Prompt recognition and management of these heterogenous disorders is required to improve patient outcomes. We perform a scoping review of the existing literature on the key features of these rare syndromes.
血清铁蛋白升高是巨噬细胞活化的标志物，与死亡率增加相关。高铁蛋白血症综合征包括噬血细胞性淋巴组织细胞增生症（HLH）和巨噬细胞活化综合征（MAS）、灾难性抗磷脂综合征（CAPS）、感染性休克、成人斯蒂尔病（AOSD）以及与新型冠状病毒肺炎相关的多炎症综合征（MIS-C/A），其特征为强烈炎症及其后遗症。需要对这些异质性疾病进行及时识别和管理，以改善患者预后。我们对现有文献中关于这些罕见综合征关键特征的内容进行了范围综述。
