Hu Juan, Zheng Huiqiu, Wu Yan, Yan Qing, Zhang Minghao, Sun Shikun, Gong Meidi, Zheng Rao, Jia Shujing, Zhou Rui, Wu Jing
Department of Toxicology, School of Public Health, Suzhou Medical College of Soochow University, 199 Renai Road, Suzhou Industrial Park, Suzhou 215123, China.
Department of Child and Adolescent Health and Health Education, School of Public Health, Inner Mongolia Medical University, Jinshan development Zone, Hohhot, Inner Mongolia 010110, China.
Toxicol Res (Camb). 2025 Feb 27;14(1):tfaf028. doi: 10.1093/toxres/tfaf028. eCollection 2025 Feb.
Amidst a proliferation of research on air pollutants and negative pregnancy outcomes, uncertainty lingers regarding their impact on live birth rates in women receiving assisted reproductive technology (ART). This meta-analysis aims to clarify this vital issue. We searched EMBASE, PubMed, and Web of Science databases, targeting articles published prior to 2023 August 2. We pooled relative risks (RRs) and their corresponding 95% confidence intervals (95%CIs) across all included studies to assess the relationship between exposure to air pollutants and live birth rates. From an initial 5,785 citations, we identified five eligible papers with a total sample size of approximately 282,000 participants. In the year prior to oocyte retrieval, for every 10 μg/m increase in fine particulate matter (PM) (RR: 0.94, 95%CI: 0.92-0.97) and coarse particulate matter (PM) (RR: 0.95, 95%CI: 0.92-0.97), the probability of live birth decreased by 6% and 5%, respectively. For every additional ppb increase in nitrogen dioxide (NO) (RR: 0.92, 95%CI: 0.87-0.98), the likelihood of live birth decreased by 8%. This meta-analysis demonstrates adverse associations between air pollution and live birth rates in women undergoing ART. These findings highlight further elucidate the observed associations, as well as to explore potential mechanisms and implications for reproductive health.
在关于空气污染物与不良妊娠结局的研究大量涌现的背景下，对于它们对接受辅助生殖技术（ART）的女性活产率的影响仍存在不确定性。这项荟萃分析旨在厘清这一关键问题。我们检索了EMBASE、PubMed和科学网数据库，检索截至2023年8月2日之前发表的文章。我们汇总了所有纳入研究的相对风险（RRs）及其相应的95%置信区间（95%CIs），以评估接触空气污染物与活产率之间的关系。从最初的5785条文献中，我们确定了5篇符合条件的论文，总样本量约为282,000名参与者。在取卵前一年，细颗粒物（PM）每增加10μg/m（RR：0.94，95%CI：0.92 - 0.97）和粗颗粒物（PM）每增加10μg/m（RR：0.95，95%CI：0.92 - 0.97），活产概率分别降低6%和5%。二氧化氮（NO）每增加1 ppb（RR：0.92，95%CI：0.87 - 0.98），活产可能性降低8%。这项荟萃分析表明空气污染与接受ART的女性活产率之间存在不良关联。这些发现凸显了进一步阐明所观察到的关联，以及探索对生殖健康的潜在机制和影响。
