Lerer Leonard, Reynolds Eric, Varia Jeet, Blakolmer Karin, Lerer Bernard
Back of the Yards Algae Sciences, Chicago, Illinois, USA.
Biological Psychiatry Laboratory and Hadassah BrainLabs, Hadassah University Medical Center, Hebrew University, Jerusalem, Israel.
Psychedelic Med (New Rochelle). 2023 Mar 13;1(1):38-42. doi: 10.1089/psymed.2022.0001. eCollection 2023 Mar.
There is growing interest in the therapeutic potential of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) for psychiatric disorders. Although 5-MeO-DMT can be chemically synthesized, the parotoid gland secretions of (also known as the Colorado River or Sonoran Desert toad) contain 5-MeO-DMT and other molecules including bufotenine, bufagenins, bufotoxins, and indole alkylamines that may have individual clinical utility or act as to enhance the activity of 5-MeO-DMT. is currently under severe ecological pressure due to demand for natural 5-MeO-DMT and habitat loss. We established a cell line from tissue obtained by wedge biopsy of the parotoid gland and confirmed the cell-based biosynthesis of 5-MeO-DMT by liquid chromatography with tandem mass spectrometry. Cell-based biosynthesis of parotoid gland secretions is a potentially cruelty-free and sustainable source of naturally derived 5-MeO-DMT for research and drug development.
5-甲氧基-N,N-二甲基色胺（5-MeO-DMT）治疗精神疾病的潜力正受到越来越多的关注。虽然5-MeO-DMT可以化学合成，但（也被称为科罗拉多河蟾蜍或索诺兰沙漠蟾蜍）的腮腺分泌物中含有5-MeO-DMT和其他分子，包括蟾毒色胺、蟾毒配基、蟾毒素和吲哚烷基胺，这些分子可能具有个体临床效用或作为增强5-MeO-DMT活性的增效剂。由于对天然5-MeO-DMT的需求和栖息地丧失，目前正面临严重的生态压力。我们从通过楔形活检获得的腮腺组织中建立了一个细胞系，并通过液相色谱-串联质谱法确认了基于细胞的5-MeO-DMT生物合成。基于细胞的腮腺分泌物生物合成是一种潜在的无残忍且可持续的天然来源5-MeO-DMT，可用于研究和药物开发。
