Al-Imam Ahmed, Motyka Marek A, Hoffmann Beata, Magowska Anita, Michalak Michal
Department of Computer Science and Statistics, Doctoral School, Poznan University of Medical Sciences, 61-806 Poznan, Poland.
Department of Anatomy and Cellular Biology, College of Medicine, University of Baghdad, Baghdad 10047, Iraq.
Pharmaceuticals (Basel). 2023 Jun 2;16(6):831. doi: 10.3390/ph16060831.
Aboriginals of Latin America have used DMT (,-dimethyltryptamine) in ritualistic ceremonies for centuries. Nevertheless, there are limited data on web users' interest concerning DMT. We aim to review the literature and explore the spatial-temporal mapping of online search behavior concerning DMT, 5-MeO-DMT, and the Colorado River toad via Google Trends over the past 10 years (2012-2022) while using 5 search terms: ",-dimethyltryptamine", "5-methoxy-,-dimethyltryptamine", "5-MeO-DMT", "Colorado River toad", and "Sonoran Desert toad". Literature analysis conveyed novel information concerning DMT's past shamanic and present-day illicit uses, showcased experimental trials on DMT uses for neurotic disorders, and highlighted potential uses in modern medicine. DMT's geographic mapping signals originated mainly from Eastern Europe, the Middle East, and Far East Asia. In contrast, 5-MeO-DMT signals prevailed in Western Europe, Indo-China, and Australasia. Signals concerning the toad originated from the Americas, Australia, India, the Philippines, and Europe. Web users searched the most for ",-dimethyltryptamine" and "5-MeO-DMT". Three terms exhibited significant upgoing linear temporal trends: "5-MeO-DMT" (β = 0.37, < 0.001), "Sonoran Desert toad" (β = 0.23, < 0.001), and "Colorado River toad" (β = 0.17, < 0.001). The literature and Infoedemiology data provided crucial information concerning DMT's legal status, risks and benefits, and potential for abuse. Nonetheless, we opine that in the upcoming decades, physicians might use DMT to manage neurotic disorders pending a change in its legal status.
几个世纪以来，拉丁美洲的原住民一直在仪式中使用二甲基色胺（DMT）。然而，关于网络用户对DMT的兴趣的数据有限。我们旨在回顾文献，并通过谷歌趋势探索过去10年（2012 - 2022年）中关于DMT、5-甲氧基-DMT和科罗拉多河蟾蜍的在线搜索行为的时空映射，使用5个搜索词：“二甲基色胺”、“5-甲氧基-二甲基色胺”、“5-MeO-DMT”、“科罗拉多河蟾蜍”和“索诺兰沙漠蟾蜍”。文献分析传达了有关DMT过去在萨满教中的使用以及当今非法用途的新信息，展示了DMT用于治疗神经症的实验性试验，并强调了其在现代医学中的潜在用途。DMT的地理映射信号主要来自东欧、中东和远东亚洲。相比之下，5-MeO-DMT的信号在西欧、印度支那和澳大拉西亚更为普遍。关于蟾蜍的信号来自美洲、澳大利亚、印度、菲律宾和欧洲。网络用户对“二甲基色胺”和“5-MeO-DMT”的搜索最多。三个术语呈现出显著的上升线性时间趋势：“5-MeO-DMT”（β = 0.37，P < 0.001）、“索诺兰沙漠蟾蜍”（β = 0.23，P < 0.001）和“科罗拉多河蟾蜍”（β = 0.17，P < 0.001）。文献和信息流行病学数据提供了有关DMT的法律地位、风险和益处以及滥用可能性的关键信息。尽管如此，我们认为在未来几十年里，在DMT法律地位改变之前，医生可能会使用它来治疗神经症。
