Hamazaki T, Hasunuma K, Kobayashi S, Shishido H, Yano S
Atherosclerosis. 1985 Apr;55(1):107-13. doi: 10.1016/0021-9150(85)90170-4.
Forty-six elderly patients (mean age 60 years) suffering from diabetes mellitus (DM), or essential or arteriosclerotic hypertension (HT) were divided into 4 groups. Group 1 served as a control, group 2 was administered 1500 mg niceritrol, group 3 was administered 162 mg acetylsalicylic acid (ASA), and group 4 was administered both 1500 mg niceritrol and 162 mg ASA/day for 8 weeks. Niceritrol lowered serum levels of beta-lipoprotein and total cholesterol and increased HDL cholesterol, usually in 8 weeks. ASA did not affect the lipid-lowering effects of niceritrol. Platelet aggregation induced by epinephrine (1 microgram/ml), collagen (1 microgram/ml), and ADP (2 microM) was depressed in groups 2, 3 and 4. Degrees of depression were higher in groups administered ASA (groups 3 and 4) than in the group administered niceritrol alone (group 2). Plasma fibrinogen levels were lowered in groups administered niceritrol (groups 2 and 4) in 8 weeks. Apparent whole blood viscosity measured at shear rates of 37.6/s and 376/s was improved only in group 4 in 8 weeks, while hematocrit did not change during the study. Because flushing, the most frequent side effect of niceritrol, can be easily controlled by a low dose of ASA, and because the combination of the 2 drugs has some beneficial effects on blood rheology, this combination is considered worthwhile for treatment and prevention of atherosclerosis.
46例患有糖尿病（DM）、原发性或动脉硬化性高血压（HT）的老年患者（平均年龄60岁）被分为4组。第1组作为对照组，第2组给予1500毫克尼可地尔，第3组给予162毫克乙酰水杨酸（ASA），第4组给予1500毫克尼可地尔和162毫克ASA/天，持续8周。尼可地尔通常在8周内可降低血清β-脂蛋白和总胆固醇水平，并提高高密度脂蛋白胆固醇水平。ASA不影响尼可地尔的降脂作用。第2、3和4组中，由肾上腺素（1微克/毫升）、胶原蛋白（1微克/毫升）和ADP（2微摩尔）诱导的血小板聚集受到抑制。使用ASA的组（第3和4组）的抑制程度高于仅使用尼可地尔的组（第2组）。使用尼可地尔的组（第2和4组）在8周内血浆纤维蛋白原水平降低。仅在第4组中，8周时在剪切速率为37.6/秒和376/秒下测量的表观全血粘度得到改善，而在研究期间血细胞比容没有变化。由于潮红是尼可地尔最常见的副作用，低剂量的ASA可以很容易地控制它，并且由于这两种药物的组合对血液流变学有一些有益的影响，因此这种组合被认为对于动脉粥样硬化的治疗和预防是值得的。
