Jay R H, Dickson A C, Betteridge D J
Department of Medicine, University College and Middlesex School of Medicine, Rayne Institute, London.
Br J Clin Pharmacol. 1990 Jan;29(1):120-2. doi: 10.1111/j.1365-2125.1990.tb03611.x.
The usefulness of niceritrol as a lipid-lowering agent is limited by a prostaglandin-mediated flushing reaction after each dose occurring in the early stages of treatment. We have tested the effect of premedication with aspirin on the reaction to 250 mg niceritrol in 30 healthy male volunteers using both subjective and observed assessments of severity. Both 300 mg and 600 mg of aspirin significantly reduced the severity of flushing when compared with placebo. No significant difference was seen between the two dose levels. Prior dosing with aspirin may increase acceptability of niceritrol and hence improve compliance.
尼可占替诺作为一种降脂药物的效用受到限制，原因是在治疗初期每次给药后会出现前列腺素介导的脸红反应。我们用主观和观察到的严重程度评估，测试了在30名健康男性志愿者中，阿司匹林预处理对250毫克尼可占替诺反应的影响。与安慰剂相比，300毫克和600毫克的阿司匹林均显著降低了脸红的严重程度。两种剂量水平之间未观察到显著差异。预先服用阿司匹林可能会提高尼可占替诺的可接受性，从而提高依从性。
