卒中地理和种族差异原因（REGARDS）研究中的靶向代谢组学
Targeted Metabolomics in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.
作者信息
Ament Zsuzsanna, Kijpaisalratana Naruchorn, Bhave Varun M, Couch Catharine A, Garcia Guarniz Ana-Lucia, Patki Amit, Cushman Mary, Judd Suzanne E, Irvin M Ryan, Kimberly W Taylor
机构信息
Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Sci Data. 2025 Mar 6;12(1):395. doi: 10.1038/s41597-025-04746-x.
Targeted metabolomics was conducted on plasma samples from a nested case-cohort study within the biracial REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. This longitudinal study investigates health outcomes with a focus on stroke disparities across the United States, particularly in the Southeastern "Stroke Belt," where stroke risk and mortality are 2-4 times higher in the Black population. The REGARDS study recruited 30,239 Black and White participants aged 45 years or older. This dataset includes 2,377 baseline plasma samples collected between 2003 and 2007 from a stroke case-cohort sub-study, with 1,056 randomly selected cohort participants and 1,321 stroke cases. The resulting data provides a resource for investigating metabolic profiles and their potential implications for health outcomes and disparities.
针对混血的中风地理和种族差异原因（REGARDS）队列中的一项巢式病例对照研究的血浆样本进行了靶向代谢组学分析。这项纵向研究调查健康结果，重点关注美国各地的中风差异，特别是在东南部的“中风带”，那里黑人人群的中风风险和死亡率高出2至4倍。REGARDS研究招募了30239名45岁及以上的黑人和白人参与者。该数据集包括2003年至2007年间从一个中风病例对照子研究中收集的2377份基线血浆样本，其中有1056名随机选择的队列参与者和1321例中风病例。所得数据为研究代谢谱及其对健康结果和差异的潜在影响提供了资源。
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