Guo Jinkun, Que Meng, Guo Jinyan, Liu ZhongFan, Che Yan-Jun
Department of Orthopaedic Medicine Center, Clinical Medical College of Hunan University of Traditional Chinese Medicine, Brain Hospital of Hunan Provincial, Changsha, Hunan, 410007, PR China.
ShanXi University of Traditional Chinese Medicine, Third Clinical College, Taiyuan, Shanxi, 030000, PR China.
J Orthop. 2025 Feb 12;67:177-182. doi: 10.1016/j.jor.2025.02.006. eCollection 2025 Sep.
To perform therapeutic assessment of tranexamic acid on functional recovery after rotator cuff repair surgery in terms of early and mid-term follow up.
From December 2021 to April 2023, a total of 40 patients with rotator cuff injury were enrolled and randomly assigned to two groups with equal number of patients, and all patients received shoulder arthroscopic surgery before receiving either tranexamic acid or normal saline managements. Patients in the experimental group, group A, treated with 2g tranexamic acid (diluted with normal saline to 20ml) via intra-articular injection, while patients in the control group (group B) received 20ml normal saline management. The whole process was conducted in accordance with randomized double-blind controlled trials. Clinical outcomes were assessed preoperatively and postoperatively via American Shoulder and Elbow Surgeons (ASES) score, a UCLA shoulder rating, a CONSTANT score, and visual analog scale (VAS). Early and mid-term follow-up were performed at 1 week, 1 month, 3 months, and 6 months after surgery.
The ASES score and CONSTANT score at 1 month, 3 months and 6 months after operation in the tranexamic acid group were higher than those in the normal saline group (p < 0.05). Meanwhile, the UCLA score at 3 months and 6 months after operation in the tranexamic acid group was higher than that in the normal saline group (p < 0.05). In addition, the muscle strength score and external rotation value at 6 months after operation in the tranexamic acid group and normal saline group were higher than those in the normal saline group (p < 0.05). There was no significant difference in the VAS score between the two groups at each observation cut-off point (p > 0.05).
Injection of tranexamic acid after rotator cuff repair surgery plays an positive role on the recovery of patients muscle strength and tone as well as shoulder flexibility. Therapeutic assessment demonstrates the favorable clinic efficacy either early or mid-term follow-up.
通过早期和中期随访，对氨甲环酸在肩袖修复术后功能恢复方面进行治疗评估。
2021年12月至2023年4月，共纳入40例肩袖损伤患者，随机分为两组，每组患者数量相等，所有患者在接受氨甲环酸或生理盐水处理前均接受肩关节镜手术。实验组A组患者通过关节内注射2g氨甲环酸（用生理盐水稀释至20ml），而对照组B组患者接受20ml生理盐水处理。整个过程按照随机双盲对照试验进行。术前和术后通过美国肩肘外科医师（ASES）评分、加州大学洛杉矶分校（UCLA）肩部评分、常数（CONSTANT）评分和视觉模拟量表（VAS）评估临床结果。术后1周、1个月、3个月和6个月进行早期和中期随访。
氨甲环酸组术后1个月、3个月和6个月的ASES评分和CONSTANT评分高于生理盐水组（p<0.05）。同时，氨甲环酸组术后3个月和6个月的UCLA评分高于生理盐水组（p<0.05）。此外，氨甲环酸组术后6个月的肌肉力量评分和外旋值高于生理盐水组（p<0.05）。两组在各观察截止点的VAS评分无显著差异（p>0.05）。
肩袖修复术后注射氨甲环酸对患者肌肉力量和张力以及肩部灵活性的恢复具有积极作用。治疗评估表明，无论是早期还是中期随访均具有良好的临床疗效。
