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骨髓细胞与基质细胞共培养中原始造血祖细胞的集落形成。

Colony formation by primitive haemopoietic progenitors in cocultures of bone marrow cells and stromal cells.

作者信息

Gordon M Y, Hibbin J A, Kearney L U, Gordon-Smith E C, Goldman J M

出版信息

Br J Haematol. 1985 May;60(1):129-36. doi: 10.1111/j.1365-2141.1985.tb07393.x.

DOI:10.1111/j.1365-2141.1985.tb07393.x
PMID:4005173
Abstract

Human bone marrow contains a class of human haemopoietic progenitor cells that adhere to cultured marrow stromal cells and form colonies of blast cells. These progenitor cells are found in the non-adherent mononuclear fraction of normal human bone marrow. They are not in active cell cycle and do not express Ia-like (HLA-DR) antigens but appear to be capable of self-renewal in vitro. These properties indicate that they should be classified as members of the primitive haemopoietic progenitor cell compartment.

摘要

人类骨髓含有一类人类造血祖细胞，它们黏附于培养的骨髓基质细胞并形成原始细胞集落。这些祖细胞存在于正常人骨髓的非黏附单核细胞部分。它们不处于活跃的细胞周期，也不表达Ia样（HLA-DR）抗原，但似乎在体外具有自我更新能力。这些特性表明它们应被归类为原始造血祖细胞区室的成员。

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Colony formation by primitive haemopoietic progenitors in cocultures of bone marrow cells and stromal cells.骨髓细胞与基质细胞共培养中原始造血祖细胞的集落形成。
Br J Haematol. 1985 May;60(1):129-36. doi: 10.1111/j.1365-2141.1985.tb07393.x.
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引用本文的文献

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CFU-F circulating in cord blood.脐血中循环的集落形成单位-成纤维细胞（CFU-F）
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Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.纤溶酶原激活剂介导的蛋白水解活性促使内皮细胞释放碱性成纤维细胞生长因子-硫酸乙酰肝素复合物。
J Cell Biol. 1990 Mar;110(3):767-75. doi: 10.1083/jcb.110.3.767.
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