Fang Angela, Anderson Riana Elyse, Carter Sierra, Eckstrand Kristen, Hsu Kean J, Jones Shawn, Kryza-Lacombe Maria, Peckham Andrew, Siegle Greg J, Uddin Lucina Q, Weierich Mariann, Woody Mary L, Illes Judy
University of Washington, Seattle, WA, USA.
Columbia University, New York, NY, USA.
J Clin Transl Sci. 2025 Jan 22;9(1):e37. doi: 10.1017/cts.2025.5. eCollection 2025.
Clinical translational neuroscience (CTN) is positioned to generate novel discoveries for advancing treatments for mental health disorders, but it is held back today by the siloing of bioethical considerations from critical consciousness. In this article, we suggest that bioethical and critical consciousness can be paired to intersect with structures of power within which science and clinical practice are conducted. We examine barriers to the adoption of neuroscience findings in mental health from this perspective, especially in the context of current collective attention to widespread disparities in the access to and outcomes of mental health services, lack of representation of marginalized populations in the relevant sectors of the workforce, and the importance of knowledge that draws upon multicultural perspectives. We provide 10 actionable solutions to confront these barriers in CTN research, as informed by existing frameworks such as structural competency, adaptive calibration models, and community-based participatory research. By integrating critical consciousness with bioethical considerations, we believe that practitioners will be better positioned to benefit from cutting-edge research in the biological and social sciences than in the past, alert to biases and equipped to mitigate them, and poised to shepherd in a robust generation of future translational therapies and practitioners.
临床转化神经科学（CTN）旨在为推进精神健康障碍的治疗方法带来新的发现，但如今它却因生物伦理考量与批判性意识的分离而受到阻碍。在本文中，我们认为生物伦理与批判性意识可以结合起来，与科学研究和临床实践所处的权力结构相互交织。我们从这一角度审视了精神健康领域采用神经科学研究成果的障碍，特别是在当前人们共同关注精神健康服务的可及性和治疗效果方面广泛存在的差异、劳动力相关领域中边缘化人群代表性不足，以及借鉴多元文化视角的知识的重要性的背景下。我们依据结构胜任力、适应性校准模型和基于社区的参与性研究等现有框架，提供了10条可付诸行动的解决方案，以应对CTN研究中的这些障碍。通过将批判性意识与生物伦理考量相结合，我们相信从业者将比过去更有能力从生物科学和社会科学的前沿研究中受益，能够警惕偏见并具备减轻偏见的能力，并有准备引领未来强大的转化疗法和从业者的产生。
