Chen Chen, Du Yan, Nie Rongzu, Wang Shuangshuang, Wang Hang, Li Peifeng
College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China.
College of Food Science and Engineering, National Engineering Research Center of Wheat and Corn Further Processing, Henan University of Technology, Zhengzhou, China.
Front Cell Dev Biol. 2025 Feb 20;13:1542967. doi: 10.3389/fcell.2025.1542967. eCollection 2025.
The Notch signaling pathway is an evolutionarily conserved intercellular signaling cascade that regulates a number of cellular processes, including cell development, proliferation, apoptosis, and genome stability. The Notch signaling pathway is pervasive in the human body, affecting tumorigenesis and progression, which is one of the most significant signaling pathways in this regard, influencing various receptors and cellular functions of tumor cells. Aberrant expression or mutation of Notch has been linked to the onset and progression of a variety of malignant tumors. In this review, we discussed the mechanism of Notch signaling in lung, liver and colorectal cancer and explored future strategies and directions for cancer treatment by modifying the Notch signaling pathway.
Notch信号通路是一种在进化上保守的细胞间信号级联反应，它调节许多细胞过程，包括细胞发育、增殖、凋亡和基因组稳定性。Notch信号通路在人体中普遍存在，影响肿瘤发生和进展，在这方面它是最重要的信号通路之一，影响肿瘤细胞的各种受体和细胞功能。Notch的异常表达或突变与多种恶性肿瘤的发生和进展有关。在这篇综述中，我们讨论了Notch信号在肺癌、肝癌和结直肠癌中的作用机制，并探讨了通过调节Notch信号通路进行癌症治疗的未来策略和方向。
