Paiement J, Joly L P
Biochim Biophys Acta. 1985 Jun 11;816(1):179-81. doi: 10.1016/0005-2736(85)90406-7.
Acidic phospholipids have been shown to form complexes with methyl mercury chloride, at physiological pH, in vitro. To check if this interaction had any effect on the physical properties of membranes made with these lipids, the specific resistance of phosphatidylserine bilayers was monitored, as a function of time, in the absence and in the presence of methyl mercury chloride in the bathing solution. While the resistance of the bilayer remained constant in the absence of the toxic, it dropped an average of 17% in four hours in the presence of 100 microM methyl mercury chloride. Such observations suggest that the physical integrity of these membranes is modified by the interaction with organic mercury. This result may be relevant to the observed degeneration of nerve membranes in Minamata disease.
在生理pH值条件下，体外实验已表明酸性磷脂可与氯化甲基汞形成复合物。为检验这种相互作用是否会对由这些脂质构成的膜的物理性质产生影响，研究人员监测了磷脂酰丝氨酸双层膜的比电阻，该比电阻是在无氯化甲基汞和有氯化甲基汞的两种情况下，作为时间的函数进行监测的。在不存在这种毒物时，双层膜的电阻保持恒定，而在含有100微摩尔氯化甲基汞的情况下，其电阻在四小时内平均下降了17%。这些观察结果表明，这些膜的物理完整性会因与有机汞的相互作用而改变。这一结果可能与水俣病中观察到的神经膜退化现象相关。
