嘌呤霉素对分离的大鼠脂肪细胞中糖转运的影响。
Effect of puromycin on sugar transport in isolated rat adipocytes.
作者信息
Kubo K, Foley J E
出版信息
Biochim Biophys Acta. 1985 Jul 11;817(1):187-9. doi: 10.1016/0005-2736(85)90082-3.
PMID:4005255
Abstract
This study was performed to determine whether puromycin effects sugar transport into isolated rat adipocytes. Time-course and kinetic studies demonstrated that puromycin competitively inhibited 3-O-methylglucose transport. The data indicate that there is an acute effect of puromycin on sugar transport via competitive inhibition that is independent of the inhibition of protein synthesis.
摘要
本研究旨在确定嘌呤霉素是否影响糖转运至分离的大鼠脂肪细胞中。时间进程和动力学研究表明，嘌呤霉素竞争性抑制3-O-甲基葡萄糖的转运。数据表明，嘌呤霉素通过竞争性抑制对糖转运有急性作用，且该作用独立于对蛋白质合成的抑制。
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