Shuai Jing, Liu Maoyu, Hou Jialing, Chen Yu, Jiang Jun, Yu Jing, Yin Liang
The General Hospital of the PLA Western Theater Command, Central Sterile Supply Department, Chengdu, Sichuan, China.
The General Hospital of the PLA Western Theater Command, Pain Management Department, Chengdu, Sichuan, China.
Rev Inst Med Trop Sao Paulo. 2025 Mar 3;67:e16. doi: 10.1590/S1678-9946202567016. eCollection 2025.
Hospital-associated infections (HAIs) pose significant risks in clinical settings, and sterile supply centers management plays a crucial role in infection control. This systematic review and meta-analysis aimed to evaluate the impact of supply center management on the incidence of HAIs and adverse events. The systematic review encompassed studies that compared supply center management protocols with standard care. The PRISMA guidelines were followed to search seven databases for relevant studies. The meta-analysis calculated pooled odds ratios (OR) for HAIs and adverse events, and heterogeneity was assessed using Tau2, Chi-squared, and I2 statistics. Eight studies were included in the final analysis, each assessing intervention efficacy. The results revealed a significant reduction in HAIs (pooled OR=0.3; 95%CI [0.19; 0.49]). Adverse events were also significantly reduced (pooled OR=0.15; 95%CI [0.09; 0.25]). Heterogeneity was low for both HAIs (Tau2=0.00; I2=0%) and adverse events (Tau2=0.04; I2=19%), which indicated a consistent effect across the studies. Sterile supply center management significantly reduced the incidence of HAIs and adverse events. This suggests these interventions are effective in improving clinical outcomes and could be a vital component of infection control strategies in healthcare facilities.
医院感染（HAIs）在临床环境中构成重大风险，而无菌供应中心管理在感染控制中起着关键作用。本系统评价和荟萃分析旨在评估供应中心管理对医院感染和不良事件发生率的影响。该系统评价纳入了比较供应中心管理方案与标准护理的研究。遵循PRISMA指南在七个数据库中检索相关研究。荟萃分析计算了医院感染和不良事件的合并比值比（OR），并使用Tau2、卡方和I2统计量评估异质性。最终分析纳入了八项研究，每项研究均评估了干预效果。结果显示医院感染显著减少（合并OR = 0.3；95%CI [0.19；0.49]）。不良事件也显著减少（合并OR = 0.15；95%CI [0.09；0.25]）。医院感染（Tau2 = 0.00；I2 = 0%）和不良事件（Tau2 = 0.04；I2 = 19%）两者的异质性均较低，这表明各项研究结果具有一致性。无菌供应中心管理显著降低了医院感染和不良事件的发生率。这表明这些干预措施在改善临床结局方面是有效的，并且可能是医疗机构感染控制策略的重要组成部分。
