全结肠移植作为内脏同种异体移植一部分的首次报道。
First report of full colon transplantation as part of a visceral allograft.
作者信息
Cruz R J, Powers C, Gunabushanam V, Khanna A
机构信息
Gastrointestinal Rehabilitation and Transplant Center - GIRTC, Starzl Transplantation Institute, Pittsburgh, PA, USA.
Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
Tech Coloproctol. 2025 Mar 7;29(1):76. doi: 10.1007/s10151-025-03115-5.
BACKGROUND
The inclusion of the colon as part of intestinal and multivisceral allografts has increased in the last decade.
METHODS
We describe for the first time in the literature a full colon transplantation as a part of a visceral allograft. The new approach involves modifications of the procurement technique with preservation of all three visceral aortic branches and incorporation of the descending and sigmoid colon as a part of the allograft.
RESULT
Seventeen months after transplantation, the patient is off any parenteral nutritional support, on full oral nutrition without the need for a single antidiarrheal agent.
CONCLUSION
The introduction of this novel technique could open new opportunities for hindgut reconstruction for patients requiring visceral transplantation, with potential increase in allograft absorptive capacity and improvement in quality of life.
背景
在过去十年中，将结肠纳入肠道和多脏器同种异体移植的情况有所增加。
方法
我们在文献中首次描述了将全结肠移植作为内脏同种异体移植的一部分。新方法涉及对获取技术的改进，保留所有三个内脏主动脉分支，并将降结肠和乙状结肠纳入同种异体移植。
结果
移植17个月后，患者不再需要任何肠外营养支持，完全依靠口服营养，无需使用任何止泻药。
结论
这项新技术的引入可能为需要内脏移植的患者的后肠重建开辟新的机会，有可能提高同种异体移植的吸收能力并改善生活质量。
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