Shagass C, Roemer R A, Straumanis J J, Josiassen R C
Biol Psychiatry. 1985 Jul;20(7):701-22. doi: 10.1016/0006-3223(85)90150-7.
The purposes of this investigation were (1) to determine the extent to which single nonredundant measures, derived from optimal combinations of evoked potential (EP) amplitude measurements, could differentiate between various groups of psychiatric patients and between patients and nonpatients, and (2) to assess the replicability of such discriminations. Somatosensory, visual, and auditory EPs were recorded from 15 locations in 253 unmedicated patients and 99 nonpatients. Multivariate statistical methods were used to reduce the amplitude measurements to sets of factor scores that met specified criteria for entry into discriminant analyses between pairs of the following groups: nonpatients, neuroses, personality disorders, schizophrenias, schizotypal/borderlines, major depressives, and manics. Sensitivity, specificity, and predictive value were assessed for discriminant scores. The discriminant scores yielded many differences between groups, most of which were replicable in split-half analyses. Among these were differences between all six patient groups and nonpatients, and between schizophrenics and nonpsychotics. Split-half discriminant analyses were also performed with 12 measures that were obtained by taking the means of factor scores grouped by sensory modality, time, and spatial location; these variables, used without preselection, provided several replicable diagnostic discriminations.
（1）确定从诱发电位（EP）幅度测量的最佳组合中得出的单一非冗余测量方法在区分不同组精神科患者以及患者与非患者方面的程度；（2）评估这种区分的可重复性。从253名未用药患者和99名非患者的15个部位记录了体感、视觉和听觉诱发电位。使用多变量统计方法将幅度测量值简化为因子得分集，这些因子得分满足进入以下几组之间判别分析的指定标准：非患者、神经症、人格障碍、精神分裂症、分裂型/边缘型、重度抑郁症和躁狂症。对判别得分评估了敏感性、特异性和预测价值。判别得分在各组之间产生了许多差异，其中大多数在对半分析中是可重复的。其中包括所有六个患者组与非患者之间以及精神分裂症患者与非精神病患者之间的差异。还对通过取按感觉模态、时间和空间位置分组的因子得分的平均值获得的12项测量进行了对半判别分析；这些变量未经预选使用，提供了几种可重复的诊断区分。
